Mild Cognitive Impairment (MCI)
Conditions
Keywords
mild cognitive impairement, dementia, respiratory physiotherapy, inspiratory muscle training
Brief summary
The goal of this clinical trial is to examine the effect of a respiratory muscle strengthening program on the cognitive and physical functioning of patients with neurocognitive disorders (Mild Cognitive Impairment) or those predisposed to them. The main questions that aims to answer are: 1. Is Inpsiratory Muscle Training (IMT) feasible in people with mild cognitive impairement? 2. Could Inspiratory Muscle Training (IMT) improve congitive function in people with mild cognitive impairement? 3. Could Inspiratory Musclre training improve physical function in this population? Participants will be: 1. \< 60 age or \> 90 age 2. MMSE (Mini Mental State Examination) score ≤ 28 and ≥ 18 and follow a high intensity IMT program along with a physical - cognitive program. or just the physical - cognitive program.
Interventions
OTHERInspiratoty Muscle training
Participants will follow an IMT program through a threshold IMT device which consists of 5 set/6 breaths at 50-60% MIP for 3 months along with their usual physical and cogntive training
OTHERUsual Care
Physical and cognitive training
Sponsors
University of West Attica
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* MMSE (Mini Mental State Examination) score ≤ 28 και ≥ 18 * stable treatment related to medication
Exclusion criteria
* MMSE score \< 18 και \> 28 * psychological disorder * any contraindication to physical training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination | T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up) |
Secondary
| Measure | Time frame |
|---|---|
| Frontal Assessment Battery | T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up) |
| Addenbrooke's Cognitive Examination | T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up) |
| Time up and Go (TUG) | T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up) |
| Sit-to-Stand test | T0 at the beginning, T1 at 3 months (end of intervention), T2 at 6 months (follow-up) |
Countries
Greece
Contacts
Primary ContactIRINI PATSAKI, PhD
Backup ContactTheodoros Zekis, MSc
Outcome results
None listed