Consciousness, Level Altered
Conditions
Brief summary
In the field of general anesthesia research, the neural mechanism underlying the loss of consciousness has long been a highly core issue. It remains unclear what consciousness is and how it emerges from brain activity. By studying anesthesia and sleep, the investigators aim to reveal what happens in the brain when consciousness is lost and when it returns. Dexmedetomidine, a widely used drug in clinical anesthetic practice, plays an important role in the anesthetic process due to its unique pharmacological properties. It hardly causes respiratory depression during the sedative and hypnotic process, which makes it occupy an important position in clinical anesthetic regimens. The emergence of stereoelectroencephalography (SEEG) technology has brought new opportunities for research on anesthesia mechanisms. Compared with traditional electroencephalographic (EEG), SEEG can directly penetrate into deep brain structures to record electrical activities, enabling precise localization of brain regions closely related to consciousness regulation. At present, although there have been some studies on the effects of dexmedetomidine on EEG activities, there are still many deficiencies. Most studies have focused on simple spectral analysis of EEG signals or observations of limited brain regions, lacking comprehensive multi-dimensional research on functional connectivity between brain regions, microstates, and complexity. Through monitoring key brain regions, the SEEG technology can obtain more targeted and accurate information, thereby providing strong support for comprehensively revealing the neural mechanisms of dexmedetomidine-induced loss of consciousness.
Interventions
DRUGDexmedetomidine
Escalating concentrations until loss of responsiveness
Sponsors
Guangzhou General Hospital of Guangzhou Military Command
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Age range: 1 - 65 years old 2. BMI: 18.5 - 25.0 kg/m² 3. ASA physical status classification: I - III 4. Patients diagnosed with drug - refractory epilepsy who, after long - term monitoring of epileptic seizures, require stereo-electroencephalography (SEEG) electrode implantation based on the clinical need for monitoring their epilepsy. 5. Patients voluntarily participate in this study and sign a written informed consent form.
Exclusion criteria
1. Patients with severe arrhythmia or other organic heart diseases; 2. Patients with comorbid obstructive sleep apnea-hypopnea syndrome (OSAHS); 3. Patients with hepatic or renal dysfunction; those with a history of immunodeficiency diseases , or a history of cancer/malignant tumors, or a history of autoimmune diseases, or severe cardiovascular and cerebrovascular diseases, or other diseases that may significantly reduce life expectancy; 4. Patients with any history of diseases that may affect protocol compliance (such as severe mental disorders, disturbance of consciousness; cognitive dysfunction, drug abuse or addiction, etc.); 5. Pregnant or lactating women, or those of childbearing potential who are unwilling/unable to take effective contraceptive measures; 6. Patients with known allergies to the ingredients contained in the drugs used in this study; 7. Patients who have participated in any drug clinical trial within 6 months before the screening examination; 8. Patients who are deemed unsuitable to participate in this study by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stereo-electroencephalography | After the patient has completed the monitoring of epileptic seizures due to clinical needs, they can participate in this test. Through test completion, an average of 3 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional connectivity | through test completion, an average of 3 hours | permutation mutual information (PMI); stereo-electroencephalography assessment parameter |
| The complexity | through test completion, an average of 3 hours | examined by permutation entropy (PE); stereo-electroencephalography assessment parameter |
| Phase-amplitude coupling (PAC) | through test completion, an average of3 hours. | PAC is used to illuminate cross-frequency coordination in neurophysiological activity of electroencephalogram. stereo-electroencephalography assessment parameter |
| Directional connectivity | through test completion, an average of 3 hours | symbolic conditional mutual information (SCMI) and directionality index (DI); stereo-electroencephalography assessment parameter |
Countries
China
Outcome results
None listed