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Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study

Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07144605
Enrollment
10
Registered
2025-08-27
Start date
2024-06-15
Completion date
2025-07-20
Last updated
2025-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Molar Hypomineralization, Incisor

Keywords

CAD-CAM, Indirect restorations, Molar Incisor Hypomineralization, MIH

Brief summary

This study is about the long-term survival success of different, externally prepared fillings (Indirect restoration, CAD-CAM blocks) used in teeth with reduced mineral structure, namely Molar Incisor Hypomineralization (MIH), which is called chalk teeth in children.

Detailed description

The aim of this study was to comparatively evaluate the long-term survival times and clinical success of nano-ceramic hybrid CAD-CAM blocks, Grandio Blocs (R) (VOCO), and glass-ceramic blocks, GC INITIAL LiSi (GC AMERICA INC. USA), according to USPHS criteria, after pulpal treatment in mandibular teeth with bilateral moderate molar incisor hypomineralization.

Interventions

OTHERCAD-CAM, indirect restorations

Indirect restorations that we think will last longer than traditional filling materials in teeth with molar hypomineralization.

Sponsors

Necmettin Erbakan University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

In our study, treatment was planned for moderately affected teeth according to the MIH Severity Index. The study was designed as a prospective, randomized, split-mouth trial. Group randomization was performed using the sealed envelope technique. In the same patient, VOCO GrandioBloc (VOCO GmbH, Cuxhaven, Germany) was applied to one tooth, while a GC Initial lithium disilicate block was applied to the symmetrical contralateral tooth.

Eligibility

Sex/Gender
ALL
Age
8 Years to 15 Years
Healthy volunteers
Yes

Inclusion criteria

8-15 years old * Systemically healthy * Cooperative (Frankl 3-4) * Diagnosed with MIH for at least one permanent tooth * Symmetrical mandibular molars that fit the middle MIH classification (teeth with a tooth score of 7-9 in MIHSI) * Teeth without indication for root canal treatment * Teeth without percussion, abscess and fistula formation * Without periapical lesions * With post-eruption enamel fractures in the relevant teeth * Without mobility and pathological gingival pockets * Patients who agreed to participate in the study.

Exclusion criteria

Teeth that are suitable for mild and severe classification * Non-cooperative (Frankl 1 and Frankl 2) * Teeth with extraction indication * Teeth that require root canal treatment * Teeth with periapical lesions, abscesses and fistula formation * Patients with mobility and pathological gingival pockets

Design outcomes

Primary

MeasureTime frameDescription
the clinical status of the restorationsup to 6 months after interventionThe restorations were clinically evaluated in the oral cavity using the USPHS index.
the status of the periapical tissuesUp to the 6th monthsThe periapical tissue status was assessed according to the Periapical Index (PAI).

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026