Critically Ill
Conditions
Keywords
Weaning, re-intubation, mechanical ventilation
Brief summary
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.
Detailed description
Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation
Interventions
DEVICEParasternal intercostal thickening fraction
Parasternal intercostal thickening fraction less than 6.5%
DEVICESham parasternal intercostal thickening
Ultrasound assessment only for purpose of blinding
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial
Exclusion criteria
* patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of reintubation | Within 72 hours after extubation | need for reintubation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of weaning failure | within 72 hours post-extubation | failed spontaneous breathing trial or reintubation |
Countries
Egypt
Contacts
Primary ContactCairo university
Outcome results
None listed