Anterior Cruciate Ligament (ACL) Rupture, Posttraumatic Osteoarthritis
Conditions
Keywords
osteoarthritis
Brief summary
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
Detailed description
The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.
Interventions
PROCEDURESynovial Fluid withdrawal at the preoperative clinic visit
Synovial Fluid withdrawal at the preoperative clinic visit
PROCEDUREPlatelet-Rich Plasma (PRP) preparation and injection
Platelet-Rich Plasma (PRP) preparation and injection
PROCEDURESynovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
PROCEDURE3mL synovial fluid withdrawn at the preoperative visit
3mL synovial fluid withdrawn at the preoperative visit
Sponsors
Rush University Medical Center
Arthroscopy Association of North America
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Randomized control trial 1:1:1 study assignment (33 subjects Arm 1 two arthrocentesis withdrawals; 33 subjects Arm 2 two arthrocentesis withdrawals with PRP injection; 33 subjects Arm 3 a very small arthocentesis withdrawal and one standard arthrocentesis withdrawal and no PRP injection)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 - 50 * English-speaking * Clinical evidence of ACL rupture with swelling * Participant must be undergoing ACL reconstruction surgery
Exclusion criteria
* Age \<18 or \>50 * Presentation \>3 weeks after initial injury * Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery * \> Kellgren-Lawrence grade 2 changes on preoperative x-ray * History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of Collagen Type II Cytokine | Enrollment up to surgery | Breakdown cytokine found in damaged cartilage |
Countries
United States
Contacts
CONTACTAdam Yanke, MD, PhD
CONTACTJorge Chahla, MD, PhD
PRINCIPAL_INVESTIGATORAdam Yanke, MD, PhD
Associate Professor and Surgeon
Outcome results
None listed