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Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) (QUE 25-013)

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07141394
Acronym
CARE-VASH
Enrollment
7908
Registered
2025-08-26
Start date
2026-10-01
Completion date
2030-09-30
Last updated
2025-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Homelessness, Substance Use Disorder (SUD)

Keywords

Homeless, Substance Use Disorder, Permanent Supportive Housing, Implementation Science

Brief summary

The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Up to 40% of Veterans exit HUD-VASH within two years of attaining housing; substance use disorders (SUDs) are one of the largest causes of returns to homelessness for HEVs. CARE-VASH QUERI proposes to implement and evaluate two evidence-based SUD services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in HUD-VASH.

Detailed description

The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) program provides subsidized, permanent housing and supports to Veterans experiencing homelessness. Substance use disorders (SUDs) are a common primary or contributing factor to negative exits from HUD-VASH. The Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) QUERI will implement two evidence-based practices (EBPs) for SUDs-Medications for Addiction Treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD)-in 12 HUD-VASH sites. We will use the Replicating Effective Programs (REP) implementation bundle to support EBP implementation at all 12 sites. Half the sites (n=6) will also receive 9 months of consumer engagement (REP+CE). In a type 3 hybrid trial, we will use mixed methods to examine the impacts of REP vs. REP+CE. Using our trial data, we will develop a budget impact analysis and implementation playbook for our program partners to spread and sustain MAT and CBT-SUD in HUD-VASH.

Interventions

DRUGMedication for Addiction Treatment (MAT)

MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.

BEHAVIORALCognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)

An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.

Sponsors

University of California, Los Angeles
CollaboratorOTHER
VA Office of Research and Development
Lead SponsorFED

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Intervention model description

Investigators are implementing two evidence-based Substance Use Disorder (SUD) services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in the Department of Housing and Urban Development-VA Supportive Housing Program (HUD-VASH).

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* Homeless-experienced Veterans (HEVs) enrolled in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program.

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Sustainment of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)18-27 months post-implementation* (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management * (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit * (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits * (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session
Reach of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)18 months post-implementation* (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management * (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit * (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits
Adoption of MAT (Medications for Addiction Treatment)18 months post-implementation% (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once
Adoption of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)18 months post-implementation% (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session
Sustainment of MAT (Medications for Addiction Treatment)18-27 months post-implementation* (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription * (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply) * (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription * (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply) * (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once
Reach of MAT (Medications for Addiction Treatment)18 months post-implementation* (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription * (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply) * (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription * (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply)

Secondary

MeasureTime frameDescription
Provider experienceBaseline and 18 months post-implementationExperiences of and satisfaction with providing HUD-VASH services to HEVs with SUDs pre- and post- implementation, which will be assessed using semi-structured qualitative interviews (data will be coded from key findings in the narratives provided during the interviews).
Cost impact of Medications for Addiction Treatment (MAT) and Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD)18 months (during the course of implementation)The predominant cost of delivering MAT in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) programs is prescriber time; for CBT-SUD, the predominant cost is case manager time. We will use VA administrative data to identify visits in which MAT was prescribed or CBT-SUD was delivered. Interviews with HUD-VASH prescribers will be used to estimate minutes/visit spent on MAT, including visits in which MAT was discussed but not prescribed; at implementation sites, we will add a mandated field to templated CBT-SUD notes that indicates time spent outside the encounter (e.g., preparing for the visit).
Acute care utilization1 year after implementation by cohortEmergency department visits and hospitalizations associated with primary SUD diagnoses
Housing retention1 year after implementation by cohortDifference in the mean days homeless over 1 year of follow-up for Veterans enrolled in trial sites that received the base versus enhanced implementation strategy, versus the expected number of days homeless had they enrolled in a comparison group of all sites not engaged in the trial

Countries

United States

Contacts

Primary ContactSonya E Gabrielian, MD MPH
Sonya.Gabrielian@va.gov(310) 478-3711
Backup ContactJenny M Barnard, BA
Jenny.Barnard@va.gov(626) 367-1077

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 26, 2026