Anastomotic Leaks, Hyperglycaemia, Total Gastrectomy
Conditions
Keywords
hyperglycaemia, total gastrectomy, anastomotic leak
Brief summary
Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage. Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.
Detailed description
Although diabetes mellitus is a known risk factor for anastomotic leaks, there are few studies on the relationship between perioperative hyperglycemia and anastomotic leaks. The primary objective of our study was to demonstrate the relationship between hyperglycemia detected during anastomosis formation in the perioperative period and postoperative anastomotic leaks.
Interventions
None listed
Sponsors
Taner Abdullah
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* elective total gastrectomy * anastomotic leak after surgery * age 18-75
Exclusion criteria
* emergency procedure * \<18 years * \>75 years * ASA score \> 3
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative anastomotic leakage | 30 days after surgery | Patients who developed anastomotic leak after total gastrectomy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| diabetic hyperglysemia | intraoperative | Patients with diabetes but unregulated blood sugar |
| non-diabetic hyperglysemia | intraoperative | Patients without diabetes who became hyperglycemic due to surgical stress |
Countries
Turkey (Türkiye)
Outcome results
None listed