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Pleural Tissue Culture Versus Pleural Fluid Culture in Infected Effusion

Microbiological Value of Sonographic Guided Pleural Tissue Culture Plus Pleural Fluid Culture in Patients With Infected Pleural Fluid

Status
Enrolling by invitation
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07140003
Enrollment
30
Registered
2025-08-24
Start date
2025-07-01
Completion date
2025-10-31
Last updated
2025-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural Tissue Culture

Keywords

pleural tissue culture ,infected pleural fluid

Brief summary

comparison between the result of fluid culture and that of pleural tissue culture

Detailed description

MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID

Interventions

To assess whether pleural tissue culture can improve the identification of causative organisms in pleural infections (using the pleural fluid culture), which can aid in selecting appropriate antimicrobial therapy and improve treatment outcomes, thus may provide valuable insights into the utility of pleural tissue culture in managing pleural infection and may guide clinicians in selecting the most appropriate diagnostic approach.

Sponsors

Alexandria University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* Exudate neutrophilic pleural fluid aspirate, or met at least one or more of the following criteria: grossly frank purulent, gram stain positive for bacteria, bacterial culture positive, acidic with a pH \<7.20, low pleural fluid glucose (\<55mg/dL), and CT evidence of pleural infection.

Exclusion criteria

Pleural infections by Mycobacterium tuberculosis.Malignant effusion.Coagulation defects.

Design outcomes

Primary

MeasureTime frameDescription
initial pleural fluid and parietal pleural tissue2 weeksthe result of culture
result of cultureone monththe result of pleural fluid culture and the pleural tissue culture result

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026