Iron Absorption
Conditions
Keywords
Iron absorption, Iron losses, Iron requirements, Iron deficiency, Iron deficiency anemia, Iron isotopes
Brief summary
Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.
Interventions
OTHERStable iron isotope
Stable iron isotopes will be used to determine iron requirements.
Sponsors
Pennington Biomedical Research Center
Cornell University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and premenopausal females age 18-50 y * Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period * Willing to refrain from iron-containing supplements for the duration of the study * Willing to refrain from tobacco smoking for the duration of the study * Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study * Willing to have blood stored for future use * Able and willing to comply with study requirements and consent to participate
Exclusion criteria
* Females: pregnant or lactating or plans to become pregnant during the study period * Inability to provide informed consent and engage in informed consent procedures * Plans to relocate outside the study area
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Iron isotope composition in blood | 12 weeks | Tracer-to-tracee rate in venous blood samples collected at multiple time points |
Countries
United States
Contacts
CONTACTStephen Hennigar, PhD
Outcome results
None listed