Does the Use of HA Gel Following Third Molar Extraction Decrease the Incidence of Alveolar Osteitis?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07139340

Enrollment

Registered

2025-08-24

Start date

2016-08-30

Completion date

2017-08-01

Last updated

2025-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Osteitis

Brief summary

The study aimed to investigate the effectiveness of Hyaluronic Acid gel on decreasing the incidence of alveolar osteitis after mandibular third molar extraction.

Interventions

OTHERHA gel

Hyaluronic Acid gel 0.8% 1 mL

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Control group (No HA gel), and study group (HA gel)

Eligibility

Sex/Gender

ALL

Age

18 Years to 33 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy patients (ASA=1) * Patients need extraction of mandibular third molar * Patients can attend recalls

Exclusion criteria

* Smoking patients * Patients taking oral contraceptive pills * Bad oral hygiene

Design outcomes

Primary

Measure	Time frame	Description
Occurence of Alveolar Osteitis (AO)	7 postoperative days	Presence of empty extraction socket without healing clot indicates AO (measured by clinical inspection; Presence of AO=1, Absence of AO=0)

Secondary

Measure	Time frame	Description
Postoperative pain	7 postoperative days	Presence of postoperative pain (measured by Visual Analogue Scale (VAS) from 0 (least pain) to 10 (worst pain))

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026