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Clinical Severity of Dental Fluorosis and Associated Risk Factors Among a Group of Children in Rural Region, Dendera Center in Egypt

Clinical Severity of Dental Fluorosis and Associated Risk Factors Among a Group of Children in a Rural Region, Dendera Center in Egypt: A Cross-Sectional Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07138456
Enrollment
231
Registered
2025-08-22
Start date
2026-02-20
Completion date
2026-06-20
Last updated
2025-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Fluorosis

Keywords

prevalence, clinical severity and risk factors of dental fluorosis in a rural area in Egypt

Brief summary

The goal of our observational study is evaluation of the clinical severity of dental fluorosis and associated risk factors among a group of children (8-12 years old) in a rural region, Dendera center, Egypt. The main question it aims to answer is: What is the clinical severity of dental fluorosis and associated risk factors among a group of children (8-12 years old) in a rural region, Dendera center, Egypt?

Detailed description

Fluoride has a dual impact, it can be beneficial for dental health when consumed at optimal levels, but excessive intake can lead to a condition known as dental fluorosis (DF). Dental fluorosis, which is particularly common among children and young individuals, is a developmental enamel defect caused by excessive fluoride exposure during the critical stages of tooth formation. This condition affects both the appearance and structure of the enamel. The severity of dental fluorosis depends on various factors, including fluoride concentration in drinking water, daily intake, duration of exposure, and climatic conditions. Epidemiological studies indicate that fluorosis can affect individuals across different age groups, with cases ranging from mild dental fluorosis to severe skeletal fluorosis. Children are particularly vulnerable to its harmful effects, which are often irreversible. In rural areas, groundwater serves as the primary source of drinking water due to limited access to treated water supplies. This dependence on groundwater increases the risk of prolonged fluoride exposure, particularly among children, whose developing teeth are more susceptible to fluorosis. While several studies have documented the prevalence of dental fluorosis globally, there is a lack of data on its prevalence in rural areas of Upper Egypt, where groundwater is a key water source. This knowledge gap highlights the need for localized research to assess the extent of the issue and develop targeted interventions. Therefore, a cross-sectional study will be conducted to determine the prevalence and severity of dental fluorosis and identify associated risk factors among children in a rural area of the Dendera district, Qena governorate, Upper Egypt.

Interventions

None listed

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
8 Years to 12 Years
Healthy volunteers
Yes

Inclusion criteria

* Children age range from 8 to 12 years. * Children have lived in the area of the study since birth. * Teeth to be examined should not be covered with fillings or braces.

Exclusion criteria

* Parents or children who refuse to participate in the study. * Ethical consideration.

Design outcomes

Primary

MeasureTime frameDescription
Clinically evident dental fluorosis in permanent incisors (prevalence)Baseline (during the initial clinical examination of the child)Clinical examination (using a probe and mouth mirror in bright daily life, using ICMR index which have the following scores 0: no fluorosis /1: mild fluorosis \_ 2: moderate fluorosis / 3: severe fluorosis)

Secondary

MeasureTime frameDescription
Clinically evident dental fluorosis in all permanent teeth present other than permanent incisors (prevalence)Baseline (during the initial clinical examination of the child)Clinical examination (using a probe and mouth mirror in bright daily life, using ICMR index which have the following scores 0: no fluorosis /1: mild fluorosis \_ 2: moderate fluorosis / 3: severe fluorosis)
Risk factors of dental fluorosisbaseline (upon enrollment, after parents complete the questionnaire)Multiple choice questions (questionnaire answered by the children's parents with multiple choice questions).
Severity of dental fluorosisBaseline (during the initial clinical examination of the child)Scoring (0-3) according to Indian Council of Medical Research (ICMR) index which have the following scores 0: no fluorosis /1: mild fluorosis \_ 2: moderate fluorosis / 3: severe fluorosis.

Countries

Egypt

Contacts

Primary ContactGihad M Abdelraheem, Master
gihad.mohamed@dentistry.cu.edu.egEgypt: +201095472833
Backup ContactGhadeer M Sayed, master
ghadeer.mohamed@dentistry.cu.edu.egEgypt: +201023724105

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026