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Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07137988
Enrollment
12
Registered
2025-08-22
Start date
2024-10-03
Completion date
2024-12-31
Last updated
2025-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Young Men

Keywords

Double blinded cross-over design

Brief summary

This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.

Interventions

DIETARY_SUPPLEMENT600 mg grape seed extract

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

DIETARY_SUPPLEMENT600 mg Starch

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Sponsors

California Baptist University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* good health, nonsmokers, those not taking medications that could affect cardiovascular function

Exclusion criteria

* hypertension, muscular skeletal disorders

Design outcomes

Primary

MeasureTime frame
Heart rate recovery every minute and heart rate kinetics (tau) following exercise5 min after exercise

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026