A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07137286

Enrollment

100

Registered

2025-08-22

Start date

2025-09-11

Completion date

2027-08-31

Last updated

2025-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

LDL Hyper-responsiveness

Brief summary

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed hyper-responders, have identifiable genetic variations in genes involved in cholesterol absorption.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years of age or older * LDL-C \>170 mg/dL in response to starting a ketogenic diet

Exclusion criteria

* Patients who do not consent to blood draw for genetic testing * Those with LDL-C \<170 mg/dL on a ketogenic diet

Design outcomes

Primary

Measure	Time frame	Description
Number of Patients to have a genetic mutation	Baseline	Genetic Mutation will be defined as a mutation in ABCG5, ABCG8, APOB, APOE, CETP, CYP27A1, LDLR, LDLRAP1, LIPA, LPL, LRP6, and PCSK9 genes

Countries

United States

Contacts

Primary ContactSaad Omar

omar.saad@mayo.edu507-538-5162

Outcome results