Oligohydramnios
Conditions
Brief summary
Based on previous studies, Both sildenafil and L-arginine helped to improve idiopathic oligohydramnios. In this study, Level of improvment of oligohydramnios will be compared. As well as, NICU admission to neonates of pregnancies complicated by idiopathic oligohydramnios. The end goal is to help physicians use the best drug for their patients.
Interventions
DRUGSildenafil 25 MG
Sildenafil is a vasodilator drug which improve blood supply to placenta.Therefore, it should improve idiopathic oligohydramnios.
DRUGL-Arginine, 1000 Mg Oral Tablet
Aminoacid with vasodilator property which improve blood supply to placenta.Therefore, it should improve idiopathic oligohydramnios.
Sponsors
Kafrelsheikh University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women with gestational age between 26-37 weeks * Pregnant women whose age is \< 35 years * Woman with other indication for elective caesarean section. * Women carrying a single fetus with no major anomalies. * Initial amniotic fluid index \<8cm determined by reliable pelivabdominal ultrasound.
Exclusion criteria
* Women complaining of other obstetric disorder such as, PPROM, preeclampsia, or diabetes. * Women with chronic illness such as, chronic hypertension, autoimmune disease or kidney disease. * Women who received other treatments for oligohydramnios in current pregnancy. * Women who smoke. * Fetuses with major congenital anomaly.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of amniotic fluid index | two hours before cesarean section | Amniotic fluid index level measured before delivery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NICU admission | first day after delivery | NICU admissions rate of the neonates in the study |
| APGAR score | 5 minutes after delivery | measuring APGAR score for the neonates in the study |
Countries
Egypt
Contacts
Primary ContactIbtesam T Gadalla, MBBch
Backup ContactMostafa F El-lakany, PHD
Outcome results
None listed