Coarctation of the Aorta
Conditions
Brief summary
The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are: * patients with exercise induced hypertension have signs of hypertensive heart disease? * patients with exercise induced hypertension have increased arterial stiffness? * patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.
Interventions
None listed
Sponsors
University Medical Centre Ljubljana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients aged 18 years and older * history of coarctation of aorta repair
Exclusion criteria
* haemodynamically significant recoarctation * arterial hypertension at rest * antihypertensive therapy * associated haemodynamically significant valvular heart disease * associated complex congenital heart disease * advanced heart failure * symptomatic arrhythmias * cognitive or physical limitations to perform exercise stress testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients with EIH who also have signs of hypertensive heart disease. | At enrolment. |
| Number of patients with EIH and increased arterial stiffness. | At enrolment. |
| Number of patients with EIH and signs of hypertensive renal damage. | At enrolment. |
Countries
Slovenia
Outcome results
None listed