Former Smoker, Non-Smoker
Conditions
Keywords
Smoking, Tobacco, Vaping, Former Smoker, Non-Smoker
Brief summary
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future. This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.
Interventions
OTHERD10-phenanthrene
All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].
Sponsors
University of Minnesota
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \> 21 years of age * In good physical \& mental health * In stable physical \& mental health * Have tried vaping * Former daily cigarette smokers who quit 1-20 year ago * Non-smokers who have not used tobacco or nicotine products
Exclusion criteria
* Has any respiratory disease (ex - asthma, COPD, etc...) * Has/had high blood pressure * Has/had liver disease * Has/had cancer * Has experience negative effects when vaped previously * Pregnant or nursing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary Ratio of D10PheT/D9PhOH | 24 hours after vaping phenanthrene | The ratio of D10-phenanthrene tetraol to D9-phenanthrene phenols in the urine will determine how the lung breaks down a class of cancer-causing chemicals called Polycyclic Aromatic Hydrocarbons (PAHs). The higher this ratio the more the lungs break down these chemicals through harmful pathways, which might increase cancer risk. The lower the ratio the more the lung breaks down the chemicals through safer pathways. |
| TNE | Baseline measure | Total nicotine equivalents will be measured in the urine samples to confirm that study participants are not using tobacco or nicotine products. |
Countries
United States
Contacts
CONTACTAleksandra Alcheva
PRINCIPAL_INVESTIGATORStephen Hecht
University of Minnesota
Outcome results
None listed