Lupus
Conditions
Keywords
Cardiac imaging, cardiac magnetic resonance imaging,, cardiac computed tomography, coronary angiogram computed tomography, coronary artery calcium, epicardial adipose tissue, inflammation, systemic lupus erythematosus, sarcoidosis, vasculitis, histiocytosis, atherosclerosis, myocarditis, corticosteroids, cytokines
Brief summary
Autoimmune diseases affect a total of 5 to 10% of the population. These diseases are associated with an increased risk of developing cardiovascular pathologies. Modern cardiac imaging tools could provide a better understanding of these complications, enabling earlier diagnosis and detection of patients most at risk. Yet, the diagnostic and prognostic value of multimodal cardiac imaging in these diseases is under-researched. The current registry aimed at investigating the diagnostic and prognostic value of cardiac imaging in autoimmune and systemic disorders.
Detailed description
This is an observational prospective registry including patients with systemic disorders and autoimmune diseases who benefit from cardiac imaging. This is a single-center registry (Hôpital Pitié-Salpêtrière). Collected data at baseline include clinical, biological and imaging data. The study is not interventional. It includes data generated from routine care. The main objective is the characterization of the cardiovascular phenotype of patients with autoimmune, systemic and/or inflammatory diseases. Secondary objectives include the development and validation of prognostic biomarkers, the identification and quantification of specific risk factors for cardiovascular disease, and the evaluation of tolerance and efficacy of conventional and innovative therapies
Interventions
OTHERdata collection
data collection
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Suspected or diagnosed autoimmune, inflammatory and/or systemic disease. 2. Cross-sectional cardiac imaging including either nonenhanced cardiac computed tomography, enhanced coronary angiogram-computed tomography, or cardiac magnetic resonance imaging
Exclusion criteria
* Age \< 18 years * Objection to study participation * Patient under legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MACE (major adverse cardiovascular events) | Through study completion, an average of 10 year | Composite outcome of myocardial infarction, stroke or cardiovascular death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ASCVD (atherosclerotic cardiovascular disease) | Through study completion, an average of 10 year | Composite outcome of acute coronary syndrome, stroke and peripheral artery disease. |
| Cardiovascular events (all) | Through study completion, an average of 10 year | MACE, ASCVD, device implantation, coronary artery disease, heart failure, rhythm and conduction disorders, valvular disorders, cardiovascular interventions, fatal and non fatal. |
Contacts
CONTACTLévi-Dan Azoulay, MD, MSc
CONTACTAlban Redheuil, MD, PhD
Outcome results
None listed