Combination of Mixed Drugs vs Ibuprofen: a Randomized Clinical Trial

Cocktail of Vitamin B, Vitamin D and Melatonine VS Ibuprofen in the Surgical Third Molar Extraction. Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07133360

Acronym

CoctailRCT

Enrollment

Registered

2025-08-21

Start date

2025-02-01

Completion date

2025-05-01

Last updated

2025-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Swelling Lips &Amp; Face, Trismus

Keywords

Vitamin B, Vitamin D, Melatonine, Ibuprofen, Third Molar

Brief summary

Combination of vitamins and melatonine compared with the conventional use of ibuprofen after surgical third molar extraction

Interventions

PROCEDUREThird molar extraction

Surgical third molar extraction with conventional medication

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers, non ibuprofen allergic, presence of impacted lower third molar

Exclusion criteria

* Diseases that avoid surgical intervention

Design outcomes

Primary

Measure	Time frame	Description
Post operative pain	10 DAYS	VAS pain scale
Swelling	7 DAYS	Face measurement for swelling
Trismus	7 DAYS	Opening limitation

Secondary

Measure	Time frame	Description
Rescue analgesia	7 DAYS	Need for more medications
Inflammatory profile	7 days	Blood cytokines

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 4, 2026