Hyperpigmentation; Melanin
Conditions
Keywords
hyperpigmentation, scutellaria baicalensis, melanin index
Brief summary
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face. The study is experimental clinical pilot study as a single group pretest-posttest. A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.
Interventions
OTHERInvestigator developed cream infused with HuangQin extract
A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.
Sponsors
Mae Fah Luang University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or Female * Has at least 1 hyperpigmentation spot (size \> 3mm) on either side of the face * 30-60 y/o * Fitzpatrick skin types II-IV * Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study
Exclusion criteria
* Pregnant or lactating * Use of whitening products or treatment within 1 month before this study * Currently using contraceptives * History of allergy to any ingredient in the intervention cream * Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex) * Severe disease (i.e. immunodeficiency, cancer) * Enrolled in other clinical study within 3 month before this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of hyperpigmentation reduction property of the intervention | Week 0, 1, 2 and 4 | Measured the melanin index of the hyperpigmented area |
| Safefty profile of the intervention | Week 1, 2 and 4 | Record and collect the adverse effect from the usage of the interventional cream |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of erythema reduction property of the intervention | Week 0, 1, 2 and 4 | Measured the erythema index of the hyperpigmented area |
| Efficacy of skin hydration property of the intervention | Week 0, 1, 2 and 4 | Measured the skin hydration value of the hyperpigmented area |
Countries
Thailand
Outcome results
None listed