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Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty

Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty - A Protocol for an Observational Cohort Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07132723
Enrollment
3700
Registered
2025-08-20
Start date
2025-08-20
Completion date
2025-10-01
Last updated
2025-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroplasty, Replacement, Hip, Closed Reduction, Length of Stay

Brief summary

The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates. It is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.

Interventions

OTHERTime in minutes from admission to closed reduction

Time in minutes from admission to closed reduction measured as: From arriving time in the emergency department until the start of surgery in the operating theater.

Sponsors

Nordsjaellands Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients will be considered eligible for inclusion if they meet all of the following criteria: * Aged 18 years or older * Presented to the emergency department with a dislocated total hip arthroplasty. * Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.

Exclusion criteria

* Were primarily booked for open surgical reduction. * Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.

Design outcomes

Primary

MeasureTime frameDescription
Post procedure length of stay30 days after the closed reductionPost procedure length of stay from closed reduction until discharge from the hospital (hours)

Secondary

MeasureTime frameDescription
Admissions to Intensive care unit30 days after the closed reductionAdmissions to the intensive care unit within 30 days after the closed reduction.
Readmission30 days after dischargeReadmission within 30 days after discharge
Delirium during admissionFrom admission to discharge up to 30 days after closed reductionDefined as diagnose of delirium (F05.x, obtained from the diagnosis codes from the given admission) or the non-planned administration of haloperidol, olanzapine, risperidone, or quetiapine (as a surrogate for new onset delirium)
All-cause mortality90 days after closed reduction90 days all-cause mortality (Y/N)
Infection requiring hospital contactPost procedure until 30 days after dischargeDefined as diagnosed infection (postoperative infection (T81.4), pneumonia (J13.x-J18.x), Cystitis (N30.x, N39.0), sepsis (R65.x A40.x, A41.x), C. difficile (A04.7) obtained from the diagnose codes from the given admission) or administration of antibiotic treatment (as a surrogate for in-hospital infection
Cardiovascular complicationsFrom admission to 30 days after discharge.Defined as diagnosed arrythmia (I47.x, I48.x, I49.x), myocardial infarction (I21.x, I22.x), cerebral ischemia (I61.x, I63.x, I64.x), hemorrhage(T81), pulmonary embolism(I26.x) or deep venous thrombosis(I80.2) (obtained from the diagnosis codes from the given admission)
Acute kidney failurePost procedure until 30 days after dischargeDefined as serum creatinine increase of more than 25 μmol/L within a period of less than 48 hours. (As a surrogate for acute kidney failure)

Countries

Denmark

Contacts

Primary ContactLars H Lundstrøm, MD, PhD
lars.hyldborg.lundstroem.02@regionh.dk+4548296512
Backup ContactRikke HF Bjulf, Research fellow
rikke.helene.frølund.bjulf.01@regionh.dk

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026