Blood Glucose Concentration, Glycemic Index, Dietary Fiber, Non-alcoholic Beer
Conditions
Keywords
fiber-enriched beer, functional food, continuous glucose monitoring, postprandial glucose response
Brief summary
This study examines how various non-alcoholic beverages affect blood sugar levels. The beverages are a non-alcoholic, fiber-enriched beer, a conventional non-alcoholic beer, and a sugar solution. Participants drink one of these beverages on different days. Afterwards, a sensor on the upper arm is used to measure the sugar content in the body fluid under the skin over a period of two hours. The aim is to find out how much blood sugar concentration rises after drinking. This will be used to check whether the non-alcoholic, fiber-enriched beer has a more favorable effect on sugar metabolism than conventional beverages. Participation is voluntary, and the data will be treated confidentially.
Interventions
OTHERnon-alcoholic, fiber-enriched beer (FEB)
500 ml FEB consumed once during a test day in a randomized crossover design. Postprandial blood glucose is monitored for 120 minutes using a continuous glucose monitor (FreeStyle Libre 3).
OTHERconventional, non-alcoholic beer
500 ml conventional non-alcoholic beer consumed once during a test day in a randomized crossover design. Postprandial blood glucose is monitored for 120 minutes using a continuous glucose monitor (FreeStyle Libre 3).
OTHERglucose solution
Glucose solution containing 12.5 g glucose in 500 ml water, consumed once during a test day in a randomized crossover design. Postprandial blood glucose is monitored for 120 minutes using a continuous glucose monitor (FreeStyle Libre 3).
Sponsors
David Faeh
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged 18-60 years * Body mass index (BMI) between 18.5 and 29.9 kg/m² * Signed informed consent
Exclusion criteria
* Diagnosed diabetes * Gastrointestinal diseases * Hormonal or other metabolic diseases * Allergies or intolerances to beer ingredients * Professional sports (\>10 hours/week of intense exercise) * Special diets (e.g., low-carb, intermittent fasting) * Sleep disorders or inability to maintain regular sleep (e.g., shift work) * Pregnancy or breastfeeding * Smoking * Inability to speak German or English * Problems with alcohol, drug, or medication abuse * Inability to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incremental Area Under the Curve (iAUC) for Postprandial Blood Glucose | 0-120 minutes after beverage consumption on each test day | Incremental area under the curve for interstitial glucose concentration measured over 120 minutes after beverage consumption. Measurements obtained via continuous glucose monitoring (FreeStyle Libre 3) in a randomized crossover design. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic Index of Fiber-Enriched Beer (FEB) | 0-120 minutes after beverage consumption on each test day | Glycemic index calculated using the incremental area under the curve for blood glucose after consumption of FEB, compared to glucose solution, according to ISO 26642:2010 methodology. |
Contacts
Primary ContactDavid Fäh, Prof.Dr.med
Backup ContactNeeser Lorena, Bsc
Outcome results
None listed