Aging, Exercise, Hypertension
Conditions
Keywords
Aging, Exercise, Pathophysiology, Hypertension, Elderly, Hemodynamic Response
Brief summary
BACKGROUND: Physical exercise promotion is one of the main global goals of innumerous health and medical societies for preventing and managing noncommunicable chronic diseases (NCDs), being one of the main therapeutic for the patient with hypertension. Exercise in heated swimming pool has emerged as a potential alternative to physical exercise on the ground for the reduction of blood pressure (BP) of hypertensive patients, however, its effects on BP, as well as hemodynamic, metabolic, inflammatory and functional variables of older individuals with hypertension have not been investigated. PURPOSE: To evaluate the effects of heated water-based exercise (HEx) versus land-based exercise (LEx) on BP, arterial stiffness, endothelial function, metabolic, inflammatory and functional variables of older individuals with hypertension. METHODS: 60 older individuals (male and female) with hypertension (age \> 60 years) will be randomized in 2:2:1 ratio to HEx, LEx or control (CON) intervention. The feasibility and physiological adaptations (physical capacity, musculoskeletal and cardiovascular responses to stress, biological and biochemical markers associated with the pathophysiology of the disease and vascular adaptations) will be assessed before, after 12 weeks and after 24 weeks of follow-up. HEx and LEx training programs will be performed three times per week and will be performed for the firs 12 weeks of follow-up.
Interventions
OTHERPhysical Exercise Session in heated Swimming Pool - HEx
Warm Up - 5 minutes of stretching and heating of the joints and muscle groups to be worked; Aerobic exercise - 30 minutes of aerobic exercise (following the same control parameter of the experimental session); Resistance exercises - 20 minutes of resisted exercises, which will be divided into 6 exercises with 2 sets of 10 to 15 repetitions (following the same control parameter of the experimental session); Calm back - 5 minutes of stretching.
OTHERPhysical Exercise Session in Land- LEx
Warm up - 5 minutes of stretching and heating of the joints and muscle groups to be worked; Aerobic exercise - 30 minutes of aerobic exercise performed on treadmill and / or exercise bike (following the same control parameter of the experimental session); Endurance Exercises - 20 minutes of exercises resisted, also divided into 6 exercises with 2 sets of 10 to 15 repetitions. The large muscle groups of the upper limbs, lower limbs and trunk will be exercised in fitness machine and with free weights (following the same control parameter of the experimental session); Calm back - 5 minutes of stretching.
OTHERControl Session Without Exercise- CON
Guidance to maintain the usual level of physical activity and not to enter physical exercise programs during the 12 weeks of follow-up.
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Universidade Estadual Paulista Júlio de Mesquita Filho
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Intervention model description
HAS HEX vs HAS LEX HAS HEX vs HAS CON HAS LEX vs HAS CON
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- For the study population, the following will not be included in the study: * Smokers (avoiding acute effects of smoking on physiological measures); * Individuals with decompensated cardiovascular disease, thyroid dysfunction and / or inflammatory diseases; * Unable individuals to perform an exercise program or ergospirometric test due to physical or mental incapacity; * Individuals with hemodynamic and / or electrocardiographic changes during the ergospirometric test. * Only individuals older than 60 years, with a diagnosis of SAH for more than 6 months (stage 1 or 2), using antihypertensive medication (office BP less than 140/90 mmHg) and without medication change for at least 2 months.
Exclusion criteria
* For the study population, individuals who have less than 60% adherence to scheduled physical exercise sessions will be excluded during the study. * Individuals who change or discontinue their clinical and / or pharmacological treatment (with or without a prescription).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure change | baseline, 3 month and 6 month | 24-hour systolic and diastolic ambulatory blood pressure change from baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial stiffness | baseline, 3 month and 6 month | Carotid-femoral pulse wave velocity change from baseline |
| Brachial artery flow-mediated dilation (FMD) | baseline, 3 month and 6 month | Change from baseline in brachial artery flow-mediated dilation (FMD) (%), calculated as: (peak diameter - baseline diameter) / baseline diameter × 100, measured via ultrasound (SonoSite M-Turbo™) after 5-minute artery occlusion. |
| Maximal oxygen consumption | baseline, 3 month and 6 month | Change from baseline of maximal oxygen consumption during a progressive cardiopulmonary exercise testing |
| First ventilatory threshold (anaerobic threshold) | baseline, 3 month and 6 month | Change from baseline in the first ventilatory threshold (anaerobic threshold) will be measured by the V-slope method during a progressive cardiopulmonary exercise testing. |
| Change from baseline in the second ventilatory threshold (respiratory compensation point) | baseline, 3 month and 6 month | Change from baseline in the second ventilatory threshold (respiratory compensation point) will be determined determined as the point at which a rapid rise in ventilation/carbon dioxide output, and a fall in partial pressure of carbon dioxide output during a progressive cardiopulmonary exercise testing. |
| Exercise tolerance | baseline, 3 month and 6 month | Change from baseline of exercie duration (minutes) during a progressive cardiopulmonary exercise testing |
| Agility and balance | baseline, 3 month and 6 month | Change from baseline of the timed-up and go test performance |
| Endurance performance | baseline, 3 month and 6 month | Six-minute walking test performance change from baseline |
| Handgrip strength | baseline, 3 month and 6 month | Change from baseline of maximum isometric strength measured during handgrip strength testing (dynamometry) |
| Flexibility | baseline, 3 month and 6 month | Change from baseline of the seat-and-reach test performance |
| Lower-limb strength | baseline, 3 month and 6 month | Change from baseline of the five time sit-to stand performance |
Other
| Measure | Time frame | Description |
|---|---|---|
| Interleukin 6 | baseline, 3 month and 6 month | Change from baseline of plasma levels of Interleukin 6 |
| C-reactive protein | baseline, 3 month and 6 month | Change from baseline of plasma levels of C-reactive |
Countries
Brazil
Contacts
Primary ContactAwassi Y. Ngomane, Master
Outcome results
None listed