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Assessment of Diaphragmatic Mobility in Dyspneic Patients With Different Types of Interstitial Lung Diseases

A Prospective Study- Assessment of Diaphragmatic Role in Dyspneic Patients With Different Types of Interstitial Lung Disease

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07131072
Enrollment
100
Registered
2025-08-20
Start date
2021-02-01
Completion date
2025-06-01
Last updated
2025-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm Issues

Brief summary

dyspnea and impaired exercise capacity in IPF patients can be related, at least in part, to respiratory muscle dysfunction, in particular to diaphragm functionality. Both B-mode and M-mode ultrasound techniques have been employed to assess diaphragm excursion, which measures the distance that the diaphragm is able to move during the respiratory cycle. recent study using lung ultrasound in assessment of diaphragmatic mobility in IPF patients and found that Diaphragmatic mobility is lower in IPF patients than in healthy controls, especially during deep inspiration. The correlation between reduced FVC and diaphragmatic excursion values in IPF patients can be of interest, since it could represent an index of functional respiratory affection performed by chest ultrasound

Detailed description

Interstitial lung diseases are known to be associated with limitations in daily activities and impaired quality of life. One of the most troublesome burdens for ILD patients is dyspnea during exercise, which extends to the resting state as the disease advances. The causes of dyspnea are suggested to be a progressive decline in total lung capacity (TLC) and vital capacity, along with impairment of diffusion capacity and subsequent development of (primarily hypoxic) respiratory failure along with respiratory muscle dysfunction. Studies have supported the advantage of ultrasonography in the assessment of diaphragmatic mobility by two-dimensional (BD) or M-mode. Others reported the investigation methods, the criteria for normal and pathological diaphragmatic function, and the perspectives of development in adult patients.

Interventions

OTHERdaiphragm mobility by ultrsound

fibrosis score, alveolitis score by CT Chest

OTHERspirometry ,DLCo

FEV1, FVC, FEV1/FVC, DLCo

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* patients presented to Ain Shams University Hospital outpatient clinic by ILD due to any cause

Exclusion criteria

* Pregnant females * Patients with end stage organ failure e.g.: Renal failure, liver cell failure * Patients with malignancy elsewhere. * The patients who refuse to be entitled in the study.

Design outcomes

Primary

MeasureTime frameDescription
diaphragm mobility assessment in different types of interstitial lung diseases1 yearmeasurement of diaphragmatic excursion in cm in different types of interstitial lung diseases

Secondary

MeasureTime frameDescription
Correlation between diaphragmatic mobility and functional assessment in different ILD types1 yearfind the correlation between excursion measurements and spirometry indices, DLCO and CT fibrosis score

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026