End Stage Renal Disease on Dialysis
Conditions
Brief summary
This study aims to assess whether two blood markers - C-reactive protein (CRP) and D-dimer - can help predict cardiovascular complications in patients undergoing regular hemodialysis. Cardiovascular disease is a common and serious problem in dialysis patients, and early detection is important. the study will include 100 adult patients from the Hemodialysis Unit at Assiut University Hospital. Participants will be divided into two groups: those with and those without known heart disease. Each participant will have a one-time blood test to measure CRP and D-dimer levels. In addition, an electrocardiogram (ECG) will be done once to check for signs of heart problems.
Detailed description
This cross-sectional study is designed to explore the potential role of hematologic biomarkers in predicting cardiovascular complications among patients undergoing maintenance hemodialysis. Cardiovascular disease is a leading cause of morbidity and mortality in this population, and systemic inflammation and hypercoagulability are thought to contribute significantly to adverse outcomes. C-reactive protein (CRP) is a well-established marker of systemic inflammation, while D-dimer reflects activation of the coagulation and fibrinolytic pathways. Both biomarkers have been associated with increased cardiovascular risk in the general population, but their predictive value in hemodialysis patients remains insufficiently characterized. A total of 100 adult patients on maintenance hemodialysis will be evaluated. The population will be stratified into two groups based on the presence or absence of clinically confirmed cardiovascular disease. Laboratory analysis will include measurement of CRP and D-dimer, and cardiovascular assessment will include a standard 12-lead ECG. Clinical and demographic data will also be collected.
Interventions
DIAGNOSTIC_TESTElectrocardiogram (ECG)
A standard 12-lead ECG will be performed once per participant to assess cardiovascular status
DIAGNOSTIC_TESTC-Reactive Protein (CRP) Test
Blood samples will be collected once from all participants to measure CRP levels
DIAGNOSTIC_TESTD-dimer Test
D-dimer levels will be assessed once to evaluate thrombotic risk.
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged ≥18 years On regular hemodialysis for at least 3 months Able and willing to provide informed consent Group I: Hemodialysis patients with no clinically documented cardiovascular disease Group II: Hemodialysis patients with confirmed cardiovascular disease (by medical records, ECGs, echocardiography, or documented hospital admissions)
Exclusion criteria
* Acute or recent infection (within the past 4 weeks) Use of anticoagulant or antiplatelet therapy Active malignancy Autoimmune or chronic inflammatory disease Known bleeding or thrombotic disorders Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum CRP level among hemodialysis patients | At baseline (one-time measurement) | To assess the level of serum CRP in hemodialysis patients with and without cardiovascular disease and compare values between the two groups to explore possible associations |
| Plasma D-dimer level among hemodialysis patients | At baseline (one-time measurement) | To assess the level of plasma D-dimer in hemodialysis patients with and without cardiovascular disease and compare values between the two groups to explore possible associations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of cardiovascular abnormalities on ECG | At baseline (one-time measurement) | To assess cardiovascular status of hemodialysis patients using a standard 12-lead ECG and record the presence of abnormal findings |
Countries
Egypt
Contacts
Primary ContactMennat Allah M Ahmed, M.B.B.Ch.
Outcome results
None listed