Hypertension (HTN), Obesity &Amp; Overweight, Sedentary
Conditions
Keywords
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), High-Intensity Interval Training (HIIT), Hypertension, Sleep, Nocturnal Blood Pressure, Ambulatory Blood Pressure Monitoring, Lifestyle Intervention, Overweight/Obesity, Cardiovascular Disease, Inflammation, Extra Virgin Olive Oil, Nuts
Brief summary
This pilot study examines whether a 4-week diet and exercise intervention can improve blood pressure, heart health, and sleep in physically inactive individuals with high blood pressure and overweight or obesity.
Interventions
OTHERMIND HIIT
4 week intervention consisting of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in combination with 3 days per week of High-Intensity Interval Training (HIIT) exercise
Sponsors
Texas Woman's University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Pilot/Feasibility Study
Eligibility
Sex/Gender
ALL
Age
18 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 to 74 years old * BMI 25 - 39.9 kg/m2 (for measured BMI) * Clinically diagnosed hypertension (physical medical record showing diagnosis of hypertension) with or without current medication use (SPB \< 160 mm Hg, DBP \< 100 mm Hg) * Physically inactive \< 7,500 steps per day (measured on Fitbit over 1-week) * No current injury, illness, or joint issue that prevents participation in exercise * Able to read and speak English * Willingness to participate and give informed written consent * Willingness to share medical record indicating diagnosis of HTN and current medication use
Exclusion criteria
* Pregnant, breastfeeding, lactating * Current smoker * Food allergy or lactose intolerance * Height \> 6 foot 6 inches (78 inches) * Blood pressure ≥ 160/100 mm Hg (Contraindication to exercise testing) * History of diagnosed cardiovascular diseases including heart attack, stroke, irregular heartbeat such as atrial fibrillation, coronary artery or peripheral artery disease, or heart failure * History of liver, kidney, or metabolic disease (including type I or II diabetes) * History of cancer * Diagnosed moderate to severe obstructive sleep apnea, CPAP use, insomnia, h/o other sleep disorder * Night shift and/or rotating shift worker (current or in the past 2 years) * Current use of sleep medications or sleep aids * Excessive alcohol intake - ≥ 8 drinks per week in women, ≥ 15 drinks per week in men * History of gastric bypass or other weight loss surgery * Current use of metformin, insulin, dietary supplements or drugs for glycemic control or weight loss * Weight stable for the last 2 months (\< 5 pounds body weight change) * Currently following a special diet for weight loss (Keto, Atkins, Intermittent Fasting) * A yes response to any questions on the PAR-Q (excluding Question 6 on use of BP medications) * Exercise training (≥ 2 days per week structured aerobic and resistance training at gym) * Prior hospitalization for COVID-19 * Any medications or supplements that may alter study outcomes as determined by study PI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine the feasibility of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT in adults with HTN and overweight/obesity. | From baseline to end of treatment at 4 weeks | Adherence to the lifestyle intervention will be determined by ≥ 75% supervised exercise training visits completed and ≥ 75% dietary compliance. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to lower blood pressure in adults with HTN and overweight/obesity. | Baseline and end of intervention at 4 weeks | Clinic-based blood pressure will be measured in triplicate at each testing visit using a Welch Allyn Automated Blood Pressure Unit and 24-hour blood pressure will also be measured using SunTech Oscar 2 Ambulatory Blood Pressure Monitors |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve nocturnal blood pressure in adults with HTN and overweight/obesity. | At baseline and at the end of the 4 week intervention | Nocturnal blood pressure will be measured using SunTech Oscar 2 Ambulatory Blood Pressure Monitors |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve cardiorespiratory fitness in adults with HTN and overweight/obesity. | Baseline and end of intervention at 4 weeks | Cardiorespiratory fitness will be assessed via maximal oxygen uptake (VO2max) on a cycle ergometer |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to lower visceral fat in adults with HTN and overweight/obesity. | Baseline and end of intervention at 4 weeks | Visceral fat will be measured via dual-energy x-ray absorptiometry (DEXA) |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve quality of life in adults with HTN and overweight/obesity. | Baseline and at the end of the intervention at 4 weeks | Health-related quality of life will be measured with the 36-item Short-Form Health Survey (SF-36) |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve cardiometabolic blood biomarkers in adults with HTN and overweight/obesity. | At baseline and end of the intervention at 4 weeks | Fasting blood will be drawn, processed, and analyzed for glucose, insulin, lipids, and inflammatory markers. |
Other
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve sleep quality in adults with HTN and overweight/obesity. | At baseline and at the end of the 4 week intervention | Sleep quality will be measured using the Pittsburgh Sleep Quality Index (PSQI) and Fitbit Inspire 3 trackers. |
Countries
United States
Outcome results
None listed