TMJ Disc Disorder
Conditions
Keywords
TMJ, Disc displacement with reduction, Dextrose 5%, Arthrocentesis
Brief summary
The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with concentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with anterior disc displacement with reduction of TMJ who did not respond favorably to conservative treatment and to compare and infer which among the two procedures is more satisfactory, whether dextrose 5% injection or Arthrocentesis.
Detailed description
The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with concentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with anterior disc displacement with reduction of TMJ who did not respond favorably to conservative treatment and to compare and infer which among the two procedures is more satisfactory, whether dextrose 5% injection or Arthrocentesis.
Interventions
OTHERdextrose 5%
Dextrose, is an osmotic proliferant which acts by dehydrating the cells at the injection site which utlimately leads to release of cellular fragments that act as chemo attractants and start the inflammatory cascade leading todeposition of collagen
Arthrocentesis , a highly successful, simple and minimally invasive procedure is a safe and simple method for treatment of anterior disc displacement with reduction of TMJ both in short term and long term follow up period, where it is a procedure of removing damaged tissues &inflammatory mediators.it can be the treatment modality for the for control group
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion Criteria -Patients diagnosed with anterior disc displacement with reduction of TMJ with pain,limited mouth opening and painful clicking who underwent conservative therapy with physiotherapy but failed to receive any relief after 3 months of conservative therapy. * Age ranges from 18 to 50 years. * Patients with adequate follow up duration for outcome assessment.
Exclusion criteria
* Patients having pain or reduced mouth opening due to fracture of the condyle. * patients having any degenerative changes in the TMJ. * patients having other systemic diseases such as polyarthritis. * patients having any neurological disorders. * Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Pain Severity Measured by Numerical Rating Scale (NRS) | Measured at baseline, 3 days and 3 months after injection | Primary Outcome Measure: 1\. Change in Pain Severity Measured by Numerical Rating Scale (NRS) Pain severity will be assessed using the Numerical Rating Scale (NRS) (0-10), where 0 = no pain and 10 = severe pain. Participants will report their pain levels at each time point. The mean change in NRS scores from baseline will be calculated and analyzed . Data Aggregation: Mean change in NRS score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Maximal Interincisal Opening (MIO) Measured in Millimeters | Measured at baseline, 3 days and 3 months after injection | Maximal interincisal opening (MIO) will be measured using a sterilllized metal scale or a digital caliper, with values recorded in millimeters (mm). The mean change in MIO from baseline will be reported . Data Aggregation: Mean change in MIO (mm) with standard deviation (SD). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Presence or Absence of Joint Clicking (Binary Outcome) | Measured at baseline, 3 days and 3 months after injection | Joint clicking will be assessed as a binary outcome (Yes/No) based on clinical examination and patient-reported symptoms. The percentage of participants with joint clicking at each time point will be reported. Data Aggregation: Percentage of participants with joint clicking at each time point |
Contacts
Primary ContactSandy Maged Ibrahim, bachelor's degree
Outcome results
None listed