Drug Allergy, Penicillin Allergy
Conditions
Keywords
Nurse-led Service, Drug Provocation Test, Delabelling
Brief summary
The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services. It also seeks to assess the impact on patients' quality of life and compare resource utilization and cost-effectiveness between the nurse-allergist collaborative approach and the traditional allergist-led approach.
Detailed description
This study hypothesizes that by involving both nurses and allergists in the delabeling process and categorizing patients based on risk levels, it will achieve comparable success rates, safety, and improvements in patients' quality of life. This approach is expected to offer superior advantages in terms of time efficiency, resource utilization, and cost-effectiveness compared to traditional allergist-led services.
Interventions
DIAGNOSTIC_TESTNurse-led penicillin allergy delabelling service
Patients in this group undergo risk assessment and categorization by nurses to identify low-risk individuals for delabeling. For these patients, nurses will collaborate with allergists in the delabeling process.
DIAGNOSTIC_TESTAllergist-led penicillin allergy delabelling service
Patients assigned to this group will undergo risk assessment and delabeling led by allergists for both low-risk and high-risk cases.
Sponsors
The University of Hong Kong
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Receiving inpatient or outpatient treatment at a participating hospital during the study period; * Possessing a documented penicillin allergy label; * Underwent penicillin allergy evaluation by the nurse-allergist collaborative approach or the traditional allergist-led approach * Demographic and clinical data required for the study available.
Exclusion criteria
* Patients unable to provide a complete medication history or history of penicillin allergy; * Patients with only emergency or short-term treatment records; * Patients who have taken steroids, antihistamines, or similar medications within the last 3 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Delabelling Success Rate | 6 months | Assess the proportion of low-risk patients who are no longer considered allergic to penicillin after delabeling. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Health-Related Quality of Life | 6 months | Measure changes in patients' quality of life before and after delabeling using the validated Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q). The DrHy-Q is a 15-item instrument answered on a 5-point Likert scale, with scores ranging from 15 (no QoL impairment) to 225 (worst QoL impairment). |
| Antibiotic Usage Rate | 6 months | Evaluate changes in the usage rates of penicillin and alternative antibiotics after delabeling. |
| Age Group Analysis | 6 months | Compare delabeling success rates across different age groups (e.g., 18-30 years, 31-50 years, and 51 years and older). |
| Immunocompetence Status | 6 months | Analyze differences in delabeling success rates and safety between immunocompetent and immunocompromised patients. |
| Initial vs. Recurrent Labeling | 6 months | Compare delabeling success rates between patients with an initial penicillin allergy label and those with recurrent labels. |
Countries
Hong Kong
Contacts
CONTACTElaine Lee
Outcome results
None listed