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The Effect of an Suction Toothbrush on the Development of Ventilator-Associated Pneumonia

The Effect of an Suction Toothbrush in Intubated Intensive Care Patients on the Development of Ventilator-Associated Pneumonia: A Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07125495
Acronym
Toothbrush
Enrollment
111
Registered
2025-08-15
Start date
2025-02-01
Completion date
2025-09-20
Last updated
2026-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection, Intensive Care (ICU), Intubation, Intubation Complication

Keywords

oral care, tootbrush, intensive care, intubation, Ventilatory-associated pneumonia

Brief summary

Literature suggests that suction toothbrushes may improve oral care in intubated patients by facilitating secretion removal and reducing microaspiration. This could decrease the need for endotracheal suctioning and lower the risk of ventilator-associated pneumonia (VAP). Therefore, this study aimed to examine the effect of a suction toothbrush on the development of VAP in intubated patients.

Detailed description

in the literature examining the superiority of a suction toothbrush over another regarding the frequency of oral care practices, appropriate solution and material use in intubated patients. It is believed that a suction toothbrush will both facilitate oral care and clear oral secretions. By minimizing secretion accumulation in the mouth, it will prevent microaspiration and reduce the need for endotracheal suctioning in patients. Determining the most effective oral care method is expected to reduce the incidence of ventilator-associated pneumonia and positively impact patient mortality. Considering all this information, the aim of this study was to examine the effect of a suction toothbrush on the development of ventilator-associated pneumonia in intubated patients.

Interventions

OTHERSuction tootbrush and distiled water

All tooth surfaces, oral mucosa, and the tongue and surrounding area were cleaned every 8 hours (3x1) with distilled water and a suction toothbrush. The aspiration feature of the suction toothbrush enabled oral care and simultaneous aspiration of oropharyngeal secretions.

OTHERsuction tootbrush and .12% chlorhexidine gluconate

Every 8 hours (3x1) 15 ml of 0.12% chlorhexidine gluconate oral solution (Adıgüzel, 2015) will be used with a suction toothbrush to clean all tooth surfaces, the oral mucosa, and the tongue. The aspiration feature of the suction toothbrush allows for the aspiration of oropharyngeal secretions during oral care.

OTHEROral care sponge and with 15 ml of 0.12% chlorhexidine gluconate oral solution

All tooth surfaces, oral mucosa, and the tongue and surrounding tongue were cleaned with 15 ml of 0.12% chlorhexidine gluconate oral solution (Adıgüzel, 2015) every 8 hours (3x1) and an oral care sponge used in oral care in the intensive care unit. After oral care, oropharyngeal secretions were aspirated.

Sponsors

Koç University
Lead SponsorOTHER
Koç University Hospital
CollaboratorUNKNOWN

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients * who aged over 18 years * who underwent orotracheal intubation after admission to the ICU, * who had no known pneumonia or diagnosis of pneumonia at the time of intubation, * who were intubated for more than 48 hours, * who had no microorganisms detected in the tracheal aspirate within the first 48 hours, * who had no lesions on the oral mucous membrane before intubation, * who had no known allergy to chlorhexidine were included in the study.

Exclusion criteria

Patients * who under 18 years of age, * those with a tracheostomy, * those were intubated for less than 48 hours, * those with microorganisms detected in their tracheal aspirate within the first 48 hours, * those who underwent reintubation, * those were pregnant, * those with lesions in the oral mucosa during intensive care admission, * those with bleeding coagulation disorders or thrombocytopenia, * those admitted to intensive care from an external institution while intubated, and those with a known chlorhexidine allergy were excluded from the study.

Design outcomes

Primary

MeasureTime frameDescription
The ventilatory associated pneumonia (VAP)Patients were included 48 hours after admission to the intensive care unit and intubation. After 48 hours of intubation, the development of VAP will be considered as a positive.The development of ventilator-associated pneumonia (VAP) after entubation in the intensive care unit (Yes / no). If a patient presents signs and symptoms of VAP with both clinical Findings and laboratory findings, researchers will diagnose it as a VAP.

Countries

Turkey (Türkiye)

Contacts

PRINCIPAL_INVESTIGATORZeliha Genç, PhD

Koç University Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 24, 2026