Ageing and Geriatric Health, Cardiovascular Diseases, Climate Adaptation, Metabolic Disorders
Conditions
Keywords
Cardiovascular Diseases, Metabolic Diseases, Geriatrics, Migration, Climate Change, Health Promotion
Brief summary
The Chinese Migrant Population Health Cohort is a prospective, multi-center study jointly initiated by Professor Yong Ji, President of Harbin Medical University, and Academician Guoqiang Chen, President of Hainan Medical University, in collaboration with regional partners. It targets older adults (≥60 years) who engage in seasonal migration between cold (Heilongjiang) and tropical (Hainan) regions. The primary objective is to investigate cardiovascular and metabolic disease risks, underlying biological and environmental mechanisms, and effective preventive strategies in this unique population. Participants are recruited from both origin and destination sites and undergo standardized baseline assessments, including questionnaires, physical examinations, medical imaging, biospecimen collection (blood, stool, hair, nails), and environmental exposure monitoring. Longitudinal follow-up includes periodic reassessments, remote monitoring, and data linkage with hospital information systems to capture health outcomes. The study aims to: Define migration-related health risk profiles and disease phenotypes. Elucidate biological and environmental mechanisms influencing disease onset and progression. Develop AI-driven risk prediction models and evaluate targeted interventions through nested randomized controlled trials. Translate findings into clinical guidelines and scalable cross-regional health management models. This is the first cohort in China to systematically investigate the health impacts of seasonal migration in older adults. By integrating epidemiology, multi-omics, environmental data, and health policy translation, the study seeks to improve continuity of care, strengthen climate adaptation, and promote healthy ageing.
Interventions
OTHERNo intervention
no intervention
Sponsors
Hainan Medical College
Jinwei Tian
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 120 Years
Healthy volunteers
Yes
Inclusion criteria
1. Permanent residents of Harbin or Hainan who will continue to reside in Harbin or Hainan for the next 5 years. 2. Baseline age ≥60 years, with basic communication and comprehension abilities. 3. No confirmed diagnosis of end-stage major organic diseases (e.g., advanced heart failure, advanced liver failure, advanced kidney failure, malignant tumors). 4. Able to perform activities of daily living independently and capable of completing questionnaires and physical examinations. 5. Willing to participate in the study, provide written informed consent, accept long-term follow-up, and provide biological specimens.
Exclusion criteria
1. Occurrence of life-threatening acute events (e.g., myocardial infarction, acute heart failure, stroke) within the past 30 days. 2. Currently receiving chronic treatment with antiviral drugs (e.g., for HIV) or antipsychotic medications. 3. Presence of moderate to severe cognitive impairment preventing survey completion or follow-up cooperation. 4. Current acute infectious diseases such as influenza or fever. 5. Simultaneous participation in other interventional clinical studies. 6. Refusal to sign informed consent or unwillingness to provide biological specimens. 7. Any other condition deemed unsuitable for study participation by the investigators based on overall assessment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants Experiencing First Major Cardiovascular Event | Up to 5 years from baseline | First occurrence of myocardial infarction, stroke (ischemic or hemorrhagic), or cardiovascular death, confirmed through hospital records, death registries, and adjudication committee review. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Cognitive Function Score (MoCA) from Baseline | Baseline, 2 years, 4 years | Mean change in Montreal Cognitive Assessment score. |
| Changes in Cardiometabolic Risk Factors | Baseline, 2 years, 4 years | Longitudinal changes in blood pressure, fasting glucose, HbA1c, lipid profile, BMI, waist circumference, and body composition. |
| Number of Participants with New-Onset Metabolic Disorders | Up to 5 years from baseline | New-onset type 2 diabetes mellitus, dyslipidemia, or obesity as defined by standard clinical and laboratory criteria. |
| Number of Deaths from Any Cause | Up to 5 years from baseline | Death from any cause, verified through official death certificates and hospital records. |
| Change in EQ-5D Quality of Life Score from Baseline | Baseline, 2 years, 4 years | Changes in validated quality-of-life scales (e.g., EQ-5D). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in Plasma Metabolite Levels from Baseline | Baseline and follow-up biospecimen analyses | Relative or absolute change in concentrations of targeted metabolites identified through mass spectrometry. |
| Change in Coronary Artery Calcium Score from Baseline | Baseline and follow-up imaging | Mean change in Agatston score by CT angiography. |
| Change in Carotid Intima-Media Thickness from Baseline | Baseline and follow-up imaging | Mean change (mm) measured by carotid ultrasound. |
Countries
China
Contacts
Primary ContactJinwei Tian, Ph.D.
Backup ContactCheng Jin, Ph.D.
Outcome results
None listed