Thyroid Associated Ophthalmopathy
Conditions
Brief summary
This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and predict patient prognosis, thereby providing novel tools to support clinical management.
Interventions
OTHERImaging and ocular examinations
2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken. Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* normal participants without eyelid disorders (control group) * patients with thyroid-associated ophthalmopathy (TAO group) * cooperative participants
Exclusion criteria
* participants with pupil or cornea disorders * participants with history of eye injury
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| eye morphological parameters | through study completion, average of 5 years | Margin reflex distances(mm) |
| Blinking feature of patients with thyroid-associated ophthalmopathy | through study completion, average of 5 years | Blinking frequency |
| Ocular movement measurement | through study completion, average of 5 years | Ocular movement ability in nine gaze positions |
| Automatic orbital structures segmentation and measurement using deep learning methods | through study completion, average of 5 years | Automatic segmentation and measurement of orbital structures,such as eyeball, extraocular muscle, orbital fat, bony orbital region, optic nerves, etc |
| Automatic diagnosis, grading, staging and prediction of patients with thyroid-associated ophthalmopathy | through study completion, average of 5 years | Patients with thyroid-associated ophthalmopathy(TAO) are classified as TAO or non-TAO. Grading is classified as mild, moderate, severe and sight-threatening. Staging is classified as active and stable. |
| three-dimensional eye parameters | through study completion, average of 5 years | eyelid volume |
Countries
China
Contacts
Primary ContactJuan Ye
Outcome results
None listed