Liver Transplantation, Pain Management
Conditions
Keywords
Liver Transplantation, Intrathecal Morphine, Erector Spinae Plane Block
Brief summary
Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes. Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects. In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.
Interventions
PROCEDUREIntrathecal Morphine
An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level. Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
PROCEDUREBi-level Erector Spinae Plane Block
Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance. Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
Sponsors
Ankara Etlik City Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18-65 years * American Society of Anesthesiologists (ASA) score I-II * Body Mass Index (BMI) between 18-30 kg/m2
Exclusion criteria
* Patients under 18 and over 65 years of age * ASA score III and above * Patients with a history of bleeding diathesis * BMI below 18 or above 30 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Scores | On the operation day | Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 0st, 1st, 2nd,4th, 12th, and 24th hours after surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative opioid consumption | Intraoperative period | Remifentanil consumption for intraoperative period will be recorded |
| Postoperative Opioid Consumption | On the operation day | Opioid consumption for 24 hours will be recorded |
Countries
Turkey (Türkiye)
Contacts
Primary ContactAtakan Sezgi
Backup ContactJülide Ergil
Outcome results
None listed