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Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07122856
Enrollment
100
Registered
2025-08-14
Start date
2025-09-15
Completion date
2026-03-15
Last updated
2025-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Caregivers, Cognitive Dysfunction, Mini-Mental State Examination, Neuropsychological Tests

Brief summary

This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.

Interventions

None listed

Sponsors

Centre Hospitalier de Gonesse
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL

Inclusion criteria

* Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria * At least two MMSE evaluations spaced 12 months apart * Follow-up at the Memory Clinic of CH Gonesse

Exclusion criteria

* Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE) * Patient has moved out of the study area (outside the CH Gonesse territory)

Design outcomes

Primary

MeasureTime frame
Change in MMSE Score Over 12 Months - measured as either a decrease of ≥3 points on the Mini-Mental State Examination [MeSH] or patient institutionalization within 12 months.12 months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026