The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer
Conditions
Brief summary
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
Detailed description
The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.
Interventions
DIAGNOSTIC_TESTsaliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
Sponsors
Sindh Higher Education Commission
Liaquat University of Medical & Health Sciences
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers * patients with oral submucous fibrosis * patients with biopsy proven oral cancer
Exclusion criteria
* patients with oral infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| salivary cytology | 1 year | A method will be developed for evaluation of detection of oral cancer |
| evaluation of telomere length of salivary cells | 1 year | Telomere length will be evaluation in the saliva of three groups |
| evaluation of biochemicals of saliva | 1 year | saliva of three groups will be compared on the basis of salivary enzymes |
Other
| Measure | Time frame | Description |
|---|---|---|
| A scoring system will be developed for the screening of patients at risk of oral submucous fibrosis | 2 years | A scoring system will be developed including cytology, genetic and biochemistry and algorithm will be designed for accurate assessment of the oral cancer |
Countries
Pakistan
Contacts
Primary ContactBinafsha Manzoor Prof, SYed, PhD
Backup ContactFasiha Dr Shah, PhD
Outcome results
None listed