Necrotic Immature Permanent Incisors
Conditions
Brief summary
the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration
Detailed description
The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)
Interventions
PROCEDUREPlatelet rich fibrin
platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
9 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
• Patients free from any systemic diseases that may interfer with the normal healing process. * Maxillary traumatized or cariously exposed non-vital immature anterior teeth. * Teeth don't need for post and core as a final restoration. * Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency. * Teeth without anatomical variations
Exclusion criteria
• Immunocompromised patients * Teeth with previous endodontic treatment. * Teeth with internal or external resorption * Radiographic evidence of root fracture. * Lack of patient and parent cooperation. * Presence of periodontal pocket depth more than 4 mm.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| apical closure assessed radiographically | 12 months after treatment | radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root |
Countries
Egypt
Outcome results
None listed