Arteriovenous Malformation, Bleeding
Conditions
Keywords
Cerebral hemorrhage, cerebral arteriovenous malformation, hybrid surgery, functional prognosis, quality improvement system
Brief summary
Cerebral arteriovenous malformation (AVM) is the leading cause of brain hemorrhage in young adults, characterized by sudden onset and rapid progression. The hybrid neurosurgical operating room is a diagnostic and therapeutic platform that integrates neurointervention and microneurosurgery, offering advantages such as one-stop rapid treatment and multimodal therapeutic approaches. This study aims to focus on patients with acute cerebral AVM-related hemorrhage through a multicenter, prospective, registry-based research approach. In the hybrid neurosurgical operating room, emergency cerebral angiography, neurointerventional embolization, microsurgical resection of the vascular malformation, or minimally invasive hematoma evacuation will be performed to explore the indications and advantages of the hybrid neurosurgical operating platform in emergency AVM hemorrhage management. The study seeks to establish standardized diagnostic and treatment protocols and operational workflows for emergency AVM hemorrhage management in the hybrid operating room. Through continuous quality improvement, the study aims to further reduce patient morbidity and mortality. This research will not only enhance the diagnostic and therapeutic level of cerebral AVM-related hemorrhage and improve patient outcomes but also effectively reduce medical costs and societal burdens.
Interventions
None listed
Sponsors
Beijing Tiantan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Head CT confirmed cerebral hemorrhage, with indications for emergency surgery * Head CTA suggested that the responsible lesion may be cerebral arteriovenous malformation * Spetzler-Martin classification 1 to 4; Cerebral arteriovenous malformation Spetzler-Martin classification is as follows: ① Nidus size: small (\<3 cm) is scored as 1 point, medium (3 cm\ 6 cm) is scored as 2 points, and large (≥6 cm) is scored as 3 points; ② Adjacent brain functional areas: 0 points for non-functional areas, 1 point for functional areas; ③ Drainage veins: 0 points for superficial veins, 1 point for deep veins); * Aged 18 to 70 years old, with systemic conditions that can tolerate surgery; * Agree to surgical treatment and sign an informed consent form.
Exclusion criteria
* Consciousness disorder due to serious underlying diseases * Patients or family members who refuse surgery * Perinatal and pregnancy patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurological outcomes | 2 weeks, 3 months, 6 months after surgery | modified rankin scale (mRS), The scale runs from 0-6. Higher scores mean a worse outcome |
Secondary
| Measure | Time frame |
|---|---|
| surgical information | pre-surgery, during the surgery, perioperatively immediately after the surgery |
| Complications | 2 weeks, 3 months, 6 months after surgery |
Countries
China
Contacts
Primary ContactYuming Jiao, MD
Outcome results
None listed