Acute Myeloid Leukemia
Conditions
Keywords
Carbapenem, enterobacterials,, Antibitic sensitivity, PCR
Brief summary
Bacterial infections with carbapenem resistant pathogens are one of the major threats in immunocompromised patients, especially among cancer patients .Furthermore, Gram negative pathogens are becoming increasingly prevalent and have become an ongoing global health concern .Emergence of Gram-negative pathogens, especially Enterobacterales that avert many of the human defense mechanisms are alarmingly increasing and most of these pathogens are resistant to many of the in-use antibiotics including carbapenems .
Interventions
DIAGNOSTIC_TESTAntibiotic administration
different samples were collected from patients admitted at oncology center at sohag
DIAGNOSTIC_TESTMolecular detection of antibiotic resistance
Molecular detection of carbapenem resistant genes: * Extraction of nucleic acid from isolated organisms by boiling. * Primers will be used for detection of carbaenem resistant genes
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
4 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patients admitted to Sohag Oncology Center have different infections and isolated organism one of carbapenem resistant enterobacterales detected by antibiotic sensitivity test.
Exclusion criteria
* All patients admitted to Sohag Oncology Center having infections in different sites and isolated organisms are not one of enterobacterales and not carbapenem resistant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Isolation of causative organism | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Antibitic sensitivity test: | 2 months |
| Molecular detection of carbapenem resistant genes: | 3 months |
Countries
Egypt
Contacts
Primary ContactNoha Saber Shafik, Assistant professor
Outcome results
None listed