Eumenorrhea, Hormonal Contraception, Intrauterine Devices, Medicated
Conditions
Keywords
IUD, POPs, Progestin, sex hormone profile, physical training
Brief summary
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
Detailed description
The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.
Interventions
BEHAVIORALPhysical training
Aerobic and resistance training three times per week. Two supervised training sessions.
Sponsors
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 19-25
Exclusion criteria
* Training more than 2 times per week * Smoking * Pregnancy * Taking any medications known to affect the outcome parameters
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fat free mass | 4 months | Fat free mass measured by DXA |
| Muscle mass | 4 months | Muscle mass measured by DXA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | 4 months | Muscle strength (arm and finger strength) |
| Appetite regulatory markers | 4 months | Leptin, Ghrelin, CCK, GLP-1 |
| Lipid profile | 4 months | Lipid profile |
| Adipose tissue sex hormone receptors | 4 months | Adipose tissue sex hormone receptors |
| Muscle fiber type measured by histochemical staining | 4 months | Muscle fiber type measured by histochemical staining |
| Protein expression in skeletal muscle tissue | 4 months | Expression of Muscle protein signaling markers for muscle protein degradation and synthesis pathways |
| Resting metabolic rate | 4 months | Resting metabolic rate measured via indirect calorimetry |
| Muscle fiber cross sectional area | 4 months | Muscle fiber cross sectional area measured by histochemical stainings |
| Maximal oxygen uptake | 4 months | Maximal oxygen uptake |
Countries
Denmark
Contacts
CONTACTMette Hansen, PhD
Outcome results
None listed