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A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding

A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07115823
Acronym
GABI
Enrollment
500
Registered
2025-08-11
Start date
2025-11-01
Completion date
2026-06-30
Last updated
2025-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anaesthesia During Pregnancy

Keywords

General anaesthetic caesarean birth, Maternal mental health, Newborn bonding, Obstetric ICU admission

Brief summary

In the UK, approximately 6000 women every year undergo caesarean sections with general anaesthetic. Additionally, around 1300 women are admitted to Intensive Care Units (ICU) annually, typically due to pregnancy or childbirth complications. Some of these women are admitted to ICU for critical care immediately following a general anaesthetic caesarean section. However, there is little research on the impact of these experiences on women/birthing people and their families. This project aims to explore the impact of general anaesthetic caesarean section, with or without subsequent ICU admission, on a mother's mental health and bonding with her newborn. Women and birthing people who have undergone a caesarean section with an epidural or spinal anaesthesia can also take part in this study, so that outcomes can be compared for different types of caesarean birth.

Detailed description

Birth is a dynamic and transformative event, both on an individual and societal level and a key phase in the transition to motherhood. Many women or birthing people remain conscious during childbirth, allowing for immediate interaction and bonding activities with their newborns. However, those who undergo a General Anaesthetic Caesarean Section (GACS) are in a state of controlled unconsciousness due the effects of the general anaesthetic and therefore, will not experience their infant being born or early post-birth interactions. Additionally, a small proportion of women or birthing people require admission to Intensive Care Units (ICU) following GACS. This can result in more prolonged periods where the mother is unable to emotionally connect or interact with her newborn. Consequently, this may increase the risk of mental health issues and affect bonding experiences for the mother postnatally. Yet, the impact of these events on women and their families remains largely underexplored. This study Involves a longitudinal survey to collect prospective data on the experience of GACS compared to caesarean sections with neuraxial anaesthesia (NACS), focusing on mental health outcomes and maternal-infant bonding. The survey will include the Depression, Anxiety & Stress Scale (DASS-21), the City Birth Trauma Scale (CBTS) and the Postpartum Bonding Questionnaire (PBQ) and one question on self-harm from the Edinburgh Postnatal Depression Scale (EPDS). These measures will be collected upon completion of the initial survey and again 3 months later.

Interventions

None listed

Sponsors

Wellbeing of Women
CollaboratorOTHER
Burdett Trust for Nursing
CollaboratorOTHER
King's College London
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 years of age and over * Gave birth by caesarean section (CS) in a UK hospital within the last 12 months * Able and willing to access the internet * ICU admission following CS

Exclusion criteria

* Under 18 years of age. * Vaginal birth (including instrumental) that did not lead to GACS or NACS * CS that has not taken place in a UK hospital * CS more than 12 months ago * ICU admission immediately following CS outside of the UK. * Unable to access the internet

Design outcomes

Primary

MeasureTime frameDescription
Postnatal depression1-15 months post birthDepression scores (DASS-21)
Newborn bonding1-15 months post birthPBQ scores

Secondary

MeasureTime frameDescription
Anxiety1-15 months post birthAnxiety scores (DASS-21)
PTSD symptoms1-15 months post birth.City Birth Trauma Scale scores
Self-harm1-15 months post birthScores from self-harm question on Edinburgh Postnatal Depression Scale

Countries

United Kingdom

Contacts

Primary ContactMichelle Anderson, PhD Candidate
michelle.4.anderson@kcl.ac.uk+447957955462

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026