Anemia
Conditions
Brief summary
Literature search has shows that both ferric carboxymaltose and iron sucrose complex are equally effective. Unfortunately, local data addressing this issue is scarce. To get further local data, the current study was planned with the objective to compare the mean change in hemoglobin with ferric carboxymaltose and IV iron sources in anemic antenatal patients in our local population.
Detailed description
It was hypothesized that there was a difference in mean change in hemoglobin with ferric carboxymaltose as compared to IV iron sources in anemic antenatal patients. The findings of the study would be a valuable addition to the existing stats, and if the hypothesis stands correct, a large number of women of reproductive age would benefit from effective iron replacement therapy, with a comparatively low incidence of side effects.
Interventions
Patients were given ferric carboxymaltose as a maximum single dose of 1000 mg diluted in 250 mL of sterile 0.9% normal saline as a slow infusion over 45 minutes.
Patients received intravenous injections of iron sucrose complex, which contained 200 mg of elemental iron (equivalent to 2 ampoules of 5 ml), mixed in 100 ml of 0.9% normal saline and infused over a period of 30 minutes every other day for up to 5 doses.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Pregnant women * Aged 18 to 40 years * Presented with anemia * Any parity * Gestational age \< 12 weeks on LMP
Exclusion criteria
* Females with a history of hypertension * Type II diabetes mellitus * Gestational diabetes mellitus * Ischemic heart disease * Endocrine disorder * Hematological disorders (hemophilia, leukemia, lymphoma, or myeloma) * History of taking iron-lowering drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Increase in hemoglobin | 12 weeks | Baseline hemoglobin was subtracted from post-treatment hemoglobin to assess increase in the hemoglobin |
Countries
Pakistan
Outcome results
None listed