The Role of POLE Mutation in High Risk Endometrial Cancer.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07114653

Enrollment

150

Registered

2025-08-11

Start date

2025-09-01

Completion date

2026-12-31

Last updated

2025-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Neoplasms

Keywords

Endometrial cancer, POLE mutation

Brief summary

The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is: What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?

Detailed description

All high-risk recurrent endometrial cancer cases who were treated in a tertiary referral center will be analyzed and subjected to POLE mutation analysis. In addition, survival analysis will be used to analyze the role of POLE mutations in women with high-risk endometrial cancer. We can answers the following. 1. What is the prevalence of POLE mutations in women with high-risk endometrial cancer? 2. What is the role of POLE mutations in real world high-risk endometrial cancer?

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* women with high-risk for recurrent endometrial cancer

Exclusion criteria

* Nil

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of POLE mutation in high risk endometrial cancer	2 years	The prevalence of POLE mutations in women with high-risk for recurrent endometrial cancer

Secondary

Measure	Time frame	Description
The impact of POLE on overall survival	5 years	The impact of POLE on overall survival, compared with the other TCGA groups

Countries

Taiwan

Outcome results