Chronic Threatening Lower Limb Ischemia
Conditions
Keywords
Duplex, Angiography
Brief summary
This study aims to evaluate the accuracy of Duplex Ultrasound (DUS) in assessing infra inguinal arterial lesions in patients with chronic threatening limb ischemia compared with digital subtraction angiography (DSA) as the reference standard. By comparing sensitivity, specificity, and predictive values across arterial segments, the study seeks to determine the clinical utility of DUS as a non-invasive alternative for pre-intervention vascular mapping in chronic limb-threatening ischemia.
Interventions
RADIATIONconventional angiography
* Peak systolic velocity (PSV) * Velocity ratios * Segment visualization quality * Degree of stenosis
Sponsors
Sohag University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- 1. Clinical diagnosis of chronic threatening lower limb ischemia (rest pain, non-healing ulcer, or gangrene). 2\. Ability to provide informed consent.
Exclusion criteria
* 1\. Hemodynamically unstable patients not fit for angiography. 2. Patients with non-atherosclerotic arterial diseases (e.g., vasculitis, Buerger's disease). 3\. Known contrast allergy or renal insufficiency precluding contrast angiography. 4\. Inadequate acoustic window or inability to undergo complete DUS examination.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of DUS compared to DSA in detecting ≥50% stenosis or occlusion in femoral, popliteal, and infra popliteal arteries. | from enrollment till angioplasty (14 days mostly) | sensitivity, specificity, positive predictive value, negative predictive value |
Countries
Egypt
Contacts
Primary ContactBaraa Mohammad Abd elrahman, Bachelor degree
Outcome results
None listed