Groin Hernia, Hernioplasty, Surgical Site Infection
Conditions
Keywords
Antibiotic Prophylaxis, Wound Infection, Risk Factors
Brief summary
The role of prophylactic antibiotics in preventing surgical site infections (SSI) for clean procedures like groin hernia repair remains controversial. This study aimed to evaluate the association between antibiotic prophylaxis and SSI rates in a real-world clinical setting and to identify independent risk factors for SSI. The study prospectively followed 100 male patients undergoing elective open groin hernioplasty. Patients were categorized based on the surgeon's decision into two groups: those who received a single dose of intravenous cefazolin (Antibiotic Group) and those who did not (No Antibiotic Group). The main outcome was the rate of SSI within 30 days of surgery.
Interventions
DRUGCefazolin
A single 2g intravenous dose administered once before surgery.
Sponsors
Al-Gumhori Teaching Hospital
Sana'a University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
17 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients (aged 17-80 years) undergoing primary open groin hernioplasty. * Provided written informed consent.
Exclusion criteria
* Recurrent, emergency, or complicated (e.g., incarcerated, strangulated) hernias. * Laparoscopic repairs. * Known immunosuppression, ongoing antibiotic therapy, or a known allergy to cefazolin. * Refusal to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Surgical Site Infection (SSI) | Within 30 days post-surgery | The rate of surgical site infection diagnosed within 30 days of surgery, based on Centers for Disease Control and Prevention (CDC) clinical criteria (e.g., purulent discharge, erythema, localized pain or swelling). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Independent Risk Factors for Surgical Site Infection (SSI) | From baseline through 30 days post-surgery | Identification of baseline and operative variables independently associated with the development of SSI. This was assessed using a multivariable logistic regression model to calculate adjusted odds ratios for factors such as high Body Mass Index (BMI), prolonged operative time, and high American Society of Anesthesiologists (ASA) score. |
Countries
Yemen
Outcome results
None listed