Acute Respiratory Distress Syndrome, Community Acquired Pneumonia, Sepsis, Transcriptome
Conditions
Brief summary
This study adopted a prospective, single-center, open-label design, aiming to evaluate the efficacy of the RTI clinical outcome prediction model in predicting clinical outcomes in subjects with acute respiratory tract infections. In this study, the subjects were divided into the community-acquired pneumonia group and the sepsis group, including one baseline visit, one visit on the 7th day, and one visit on the 28th day. During the research process, blood samples will be collected at the corresponding visiting points for the validation of the predictive model.
Interventions
DIAGNOSTIC_TESTRTImodel001
This model was developed through transcriptome sequencing combined with machine learning to predict the risk of disease progression and clinical outcomes of respiratory tract infections
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Community-acquired pneumonia group * Age ≥18 years old; * Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit; ④ Comply with the diagnostic criteria for community-acquired pneumonia in the Chinese Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Adults (2016 Edition); ⑤ The time from onset to enrollment was ≤8 days. Sepsis Group * Age ≥18 years old; * Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit; * Patients who meets the sepsis 3.0 diagnostic criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any of the following occurs: 1) Death; 2) Progress to sepsis (SOFA≥2 points); 3) Follow up for 28 days. | From enrollment to the end of follow-up at 28 days |
Secondary
| Measure | Time frame |
|---|---|
| The changes of the seven-scale compared to the time of enrollment | From enrollment to the end of follow-up at 28 days |
| The changes in SOFA score compared to the time of enrollment. | From enrollment to the end of follow-up at 28 days |
Outcome results
None listed