Bovine Bone, Chronic Periodontitis, Concentrated Growth Factor
Conditions
Brief summary
The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.
Detailed description
Periodontitis is an infection-driven inflammatory disease resulting from dental plaque accumulation at the gingival margin, triggering an inflammatory response that leads to microbial alterations and may have severe consequences for the periodontium of susceptible individuals. The xenograft most commonly used in periodontal regeneration procedures is the deproteinized bovine or equine bone mineral. Platelets are known to play a significant role in guided tissue regeneration (GTR) by releasing several growth factors, such as platelet-derived growth factor (PDGF), and plasma rich in growth factors (PRGF), which are present in platelet-rich plasma (PRP), a first-generation platelet concentrate. Platelet-rich fibrin (PRF) and concentrated growth factors (CGF) are considered the second generation of platelet concentrate.
Interventions
OTHERConcentrated growth factors, collagen membrane and xenograft bone graft
Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.
OTHERCollagen membrane and xenograft bone graft
Ten sites were treated with a collagen membrane and a xenograft bone graft.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Presence of angular periodontal intra-bony defects with a pocket depth (PD) ≥ 5mm. * Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene. * Full-mouth bleeding score ≤ 25%.
Exclusion criteria
* Patients with relevant medical conditions that may affect periodontal regeneration and periodontal surgery. * Patients who have any disease or take any medication that affects the normal number or function of platelets. * Smokers. * Pregnant or lactating women. * Patients in whom periodontal surgery had previously been carried out on the selected site. * Patients with aggressive periodontitis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing Pocket depth | 6 months post-procedure | Probing Pocket depth (PPD) was measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level | 6 months post-procedure | Clinical attachment level (CAL) was measured. |
| Bleeding on probing | 6 months post-procedure | Bleeding on probing (BOP) was measured. |
| Plaque index | 6 months post-procedure | Plaque index (PI) was measured. |
Countries
Egypt
Outcome results
None listed