Non-invasive Diffusion-weighted Imaging, Magnetic Resonance Cholangiopancreatography, Diagnosis, Neoplastic Biliary Obstruction
Conditions
Brief summary
This study aims to evaluate the diagnostic value of non-invasive diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting neoplastic biliary obstruction.
Detailed description
Both surgeons and endoscopists value accurate approaches for identifying the source of biliary stricture in patients with obstructive jaundice. Cholangiocarcinoma or a benign stricture may cause a biliary stricture. Many imaging methods were used to diagnose the cause of biliary stricture. Diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a non-invasive imaging modality that can potentially differentiate between malignant and benign biliary obstructions based on the measurement of water diffusion in tissues. The gold standard of the research is endoscopic retrograde cholangiopancreatography (ERCP) and histology. Patients' diagnoses and follow-up were further verified by ERCP or histopathology.
Interventions
Patients who are scheduled for magnetic resonance cholangiopancreatography and have undergone conventional imaging
Sponsors
The General Authority for Teaching Hospitals and Institutes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (≥18 years) with clinically suspected biliary obstruction (e.g., jaundice, elevated liver enzymes, cholestasis). * Patients who are scheduled for magnetic resonance cholangiopancreatography (MRCP) and have undergone conventional imaging \[ultrasound or computed tomography (CT)\]. * Patients who will undergo further invasive procedures, e.g., endoscopic retrograde cholangiopancreatography (ERCP), biopsy.
Exclusion criteria
* Patients with contraindications to magnetic resonance imaging (MRI) (e.g., pacemakers, metal implants). * Patients who have previously undergone major biliary surgery or stent placement. * Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of magnetic resonance cholangiopancreatography | Immediately after magnetic resonance cholangiopancreatography (Up to 1 hour) | Sensitivity of magnetic resonance cholangiopancreatography to predict of a tumor will be recorded. |
Countries
Egypt
Contacts
Primary ContactHekmat S Baumey, MD
Outcome results
None listed