Intensive Care Patients, Osteoarticular Infections, Prosthetic Joint Infection
Conditions
Keywords
Osteoarticular sepsis, sepsis, osteoarticular prothetis, intensive care, critical care, prosthetic joint infection
Brief summary
This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated diagnosis of joint prosthesis infection. Data from this study will be combined with that from the OASIS study (APHP241174/ ID-RCB: 2024-A01769-38) concerning osteoarticular sepsis on prosthetic material in critical care of living patients. The aim of this study is to improve our knowledge of the profile, care trajectories and outcomes of patients hospitalized in critical care in the context of osteoarticular material sepsis. The results of the study could help identify at-risk populations and improve management strategies for patients with osteoarticular sepsis.
Interventions
OTHERGlobal cohort
All deceased patients admitted to intensive care during the study period and satisfying the eligibility criteria.
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient aged 18 years or older. * Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022, lasting at least 48 hours, with a prosthetic joint infection (hip, knee, or shoulder prosthesis infection) as the primary or associated diagnosis. * Deceased patient who had not refused data processing.
Exclusion criteria
* Infection involving osteosynthesis material * Infection involving spinal instrumentation * Patient with multiple infected prostheses * Recurrence of prosthetic infection with the same microorganism as a previous episode * Patient under legal protection * Pregnant or breastfeeding patient * Patient deprived of liberty
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epidemiological description of deceased patients | 2 years | Demographic data, medical history, history of Periprosthetic Joint Infection (timing, diagnosis, surgery, antibiotics), data in intensive care unit (leng of stay, organ failure, drugs and mechanical support, biological data) and outcome (time of death within 2 years after admission to Intensive Care Units). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Composite endpoint reflecting poor clinical outcome | 2 years | * Mortality, measured in critical care, at 30 days, 1 year and 2 years. * Therapeutic failure at 2 years, defined as mechanical or septic failure. * Functional failure at 2 years, defined as failure to resume walking and usual activities, to return home, or to regain autonomy. |
| Mortality at 2 years | 2 years | — |
| Epidemiological description based on the number (n) and proportion (%) of bacterial strains found in samples collected during the operation. | 2 years | Special focus on: Gram-positive bacteria (Staphylococcus, Streptococcus, Enterococcus), Gram-negative bacteria (Enterobacteriacea, Pseudmononas), slow-growing bacteria (Cutibacterium, Corynenbacteria), yeasts; resistance mechanisms (meticillin, rifampicin, quinolone, glycopeptide, ESBL, carbapenem). |
Countries
France
Contacts
CONTACTBenjamin SOYER, MD, Msc
CONTACTBenjamin CHOUSTERMAN, MD, PhD
STUDY_DIRECTORCarine PARE
Assistance Publique - Hôpitaux de Paris
Outcome results
None listed