Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

Assessment of Right Ventricular Function for Diagnosis and Prognosis After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07107347

Enrollment

100

Registered

2025-08-06

Start date

2025-09-30

Completion date

2028-03-31

Last updated

2025-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pulmonary Embolism (PE)

Keywords

acute pulmonary embolism (PE), STE, right ventricle strain, speckle tracking strain

Brief summary

Echocardiographic Assessment: Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF) Follow-up data: ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality

Detailed description

the study targets patient with acute pulmonary embolism confirmed by CTPA, without hemodynamic instability. within the first 24 hours echocardiography will be conducted, assessment of RV function by conventional measures eg, TAPSE, S', FCA and speckle tracking strain echocardiography. compare the results and its sensitivity in prediction of clinical outcomes, that will be assessed by follow up the patients for one month regarding length of hospital stay, oxygen/ventilatory support, hemodynamics support and 30 day mortality.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults ≥18 years. 2. Confirmed acute PE (via CT pulmonary angiography).(4,6) 3. Echocardiography performed within 24 hours of diagnosis.

Exclusion criteria

1. Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease). 2. History of coronary artery disease. 3. Impaired LV systolic function, ejection fraction \<50%. 4. Moderate to severe valvular heart disease. 5. Prior document of an episode of pulmonary embolism. 6. Poor acoustic window. 7. Hemodynamic instability

Design outcomes

Primary

Measure	Time frame
Primary (main): Composite of in-hospital mortality, ICU admission >7 days, or need for mechanical circulatory/ventilatory support.	30 day follow up

Secondary

Measure	Time frame
Secondary outcome: Each individual component; echocardiographic parameters as predictors.	30 day follow up

Countries

Egypt

Contacts

Primary ContactDoaa Roshdy, assistant lecturer

doaa.elenany@yahoo.com+201024588594

Outcome results