Arthritis
Conditions
Keywords
early onset arthritis
Brief summary
The prospective observational study Early STratification of acute inflammatory ARThritis (START) aims to build a platform for identification of markers for early stratification of inflammatory arthritis to ensure timely diagnosis and correct initial treatment. Management of early-stage inflammatory arthritis is a daily challenge for the rheumatologist and encompasses a range of conditions. Stratification is needed both for optimal diagnostics and for personalising therapy, but is hampered by a lack of tools. Current evaluation is inadequate for early diagnosis and treatment of inflammatory joint diseases as well as for timely diagnosis of infections. The clinical role of novel biomarkers needs to be investigated in large patient samples. In the START study, an extensive data collection will be performed to build a platform for identification and validation of biomarkers for stratification of early-stage inflammatory arthritis. The study has an ambitious goal of improving patient care by increased understanding of the disease. The project applies a unique multitude of approaches to characterisation of patients, including modern imaging techniques, analyses of synovial fluid and -biopsies, genetic and epigenetic markers, proteomics, microbiota analyses and immunological markers. The results will enable clinicians to make better informed treatment decisions for the individual patient with early-stage inflammatory arthritis.
Interventions
OTHERThis is an observational study with no intervention
This is an observational study with no intervention
Sponsors
Oslo University Hospital
Diakonhjemmet Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Arthritis\* in one or more joints of less than 12 weeks' duration\*\* * Adult patients (\> 18 years) capable of understanding and signing an informed consent form * Defined as currently active clinical synovitis (ie, swelling) in at least one joint as determined by an expert assessor which might be confirmed by ultrasonography \*\* Prior patient reported swollen joint not confirmed as arthritis by a rheumatologist is not an exclusion
Exclusion criteria
* Swollen joint related to trauma * Subject not capable of adhering to the study protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Final diagnosis | 12 months | Number of patients with a final diagnoses of the differnent forms of arthritis assed by the ICD-10 codes given by the investigator |
Countries
Norway
Contacts
Primary ContactSilje W Syversen, MD PhD
Outcome results
None listed