Liver Diseases, Liver Transplantation
Conditions
Brief summary
This retrospective cohort study investigates the long-term outcomes of ABO-incompatible (ABO-I) versus ABO-compatible (ABO-C) living donor liver transplantation (LDLT). A total of 511 patients at a single high-volume transplant center in Korea. The study aims to compare overall survival and the incidence of biliary complications.
Detailed description
This retrospective cohort study investigates the long-term outcomes of ABO-incompatible (ABO-I) versus ABO-compatible (ABO-C) living donor liver transplantation (LDLT). A total of 511 patients underwent LDLT between January 2012 and December 2022 at a single high-volume transplant center in Korea. Among them, 121 received ABO-I grafts using a rituximab-based desensitization protocol, while 390 underwent ABO-C LDLT. The study aims to compare overall survival and the incidence of biliary complications, as well as to identify risk factors specific to each group. This analysis provides insights into the long-term safety and efficacy of ABO-I LDLT in regions with low deceased donor organ availability.
Interventions
PROCEDUREliving donor liver transplantation
other intervention cannot be applied.
Sponsors
Seoung Hoon Kim
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adult patients who underwent LDLT at the study center from 2012 to 2022
Exclusion criteria
* Pediatric patients, deceased donor recipients, multi-organ transplants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of biliary complications | within 10 years post-transplantation | Statistical analyses are conducted to determine the incidence of biliary complication. |
Outcome results
None listed