Aortic Regurgitation
Conditions
Brief summary
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
Detailed description
Aortic regurgitation is relatively common, with a prevalence of 13% for men and 8,5% for women in the Framingham study (Singh et al). Patients with aortic regurgitation are evaluated regularly with echocardiography to see if progress occurs, and suitable candidates are referred for surgical repair or replacement of the aortic valve. However, an American study from 2019 showed that only 12% of cases of aortic regurgitation progressed from mild to moderate or severe over a 10 years period (Yang et al). This means that the majority of patients undergo echocardiographic evaluations without a clinical benefit. It is unclear whether these findings also apply to a Swedish population with the European definitions for aortic regurgitation. Aim: To do a retrospective analysis of patients evaluated with echocardiography in Västerås, Sweden between January 2003 and March 2025 to describe the prevalence of aortic regurgitation as well as aortic dilatation, to describe how often progress occurs in patients with mild or moderate aortic regurgitation, and finally to look at factors (clinical, echocardiographic) associated with progress of aortic regurgitation as well as outcome (mortality, MACE, cardiac surgery).
Interventions
None listed
Sponsors
Region Västmanland
Uppsala University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients investigated with echocardiography between January 2003 and March 2025 * Age ≥18 years * At least minimal aortic regurgitation * At least one additional echocardiography after the index investigation
Exclusion criteria
* Age \<18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progress of aortic regurgitation | Depending on when the patients was evaluated first, up to approximately 20 years of follow-up | Progress of aortic regurgitation from mild to moderate or severe, or moderate to severe. Progress is defined according to current European Society for Cardiology guidelines using a comprehensive echocardiographic assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgical treatment of aortic regurgitation or aortic aneurysm | Depending on when the patients was evaluated first, up to approximately 20 years of follow-up | Surgical treatment of aortic regurgitation or aortic aneurysm |
| Hospitalization for heart failure | Depending on when the patients was evaluated first, up to approximately 20 years of follow-up | Hospitalization for heart failure during follow-up |
| Hospitalization for stroke or myocardial infarction | Depending on when the patients was evaluated first, up to approximately 20 years of follow-up | Composite endpoint |
| All-cause mortality | Depending on when the patients was evaluated first, up to approximately 20 years of follow-up | All-cause mortality during follow-up |
Countries
Sweden
Contacts
Primary ContactMatthijs Velders, MD PhD
Outcome results
None listed